Nyclobate 0.05% (Shampoo)

60 ml bottle: ৳ 350.00

Medicine Details

Category Details
Generic Clobetasol propionate
Company Incepta pharmaceuticals ltd
Also available as
Nyclobate 005 cream Nyclobate 005 ointment Nyclobate 005 scalp solution Nyclobate 005 spray Nyclobate 005 lotion

Indications

  • Psoriasis
  • Recalcitrant dermatoses
  • Lichen planus
  • Discoid lupus erythematosus
  • Other skin conditions which do not respond satisfactorily to less potent steroids

Composition

  • Clobetasol Propionate Cream: Clobetasol Propionate BP 0.5 mg (0.05% w/w)
  • Clobetasol Propionate Ointment: Clobetasol Propionate BP 0.5 mg (0.05% w/w)
  • Clobetasol Propionate Scalp Application: Clobetasol Propionate BP 0.5 mg (0.05% w/w)
  • Clobetasol Propionate Shampoo: Clobetasol Propionate BP 0.5 mg (0.05% w/w)
  • Clobetasol Propionate Lotion: Clobetasol Propionate BP 0.5 mg (0.05% w/w)
  • Clobetasol Propionate Spray: Clobetasol Propionate BP 0.5 mg (0.05% w/w)

Pharmacology

  • Anti-inflammatory
  • Antipruritic
  • Vasoconstrictive
  • Inhibits late phase allergic reactions
  • Decreases mast cell density
  • Inhibits cytokine production

Dosage

  • Cream, Ointment, and Spray: Apply a thin layer twice daily
  • Occlude for enhanced effect in resistant lesions
  • Super-high potency topical corticosteroids
  • Limited to 2 consecutive weeks
  • Maximum weekly dose should not exceed 50 gm
  • Scalp Solution and Shampoo: Apply once daily to affected areas
  • Total dosage should not exceed 50 g per week
  • Discontinue if no response after one week

Administration

Cutaneous. Creams for moist or weeping surfaces, ointments for dry or scaly lesions

Interaction

Co-administered drugs that can inhibit CYP3A4 can increase systemic exposure

Contraindications

  • Rosacea
  • Acne vulgaris
  • Perioral dermatitis
  • Primary cutaneous viral infections
  • Hypersensitivity to the preparation
  • Not indicated for primarily infected skin lesions or dermatoses in children under one year of age

Side Effects

  • Hypercorticism with prolonged use
  • Local atrophic changes in the skin
  • Provocation of pustular form of psoriasis
  • Pigmentation changes
  • Hypertrichosis
  • Hypersensitivity

Pregnancy & Lactation

Limited data on use in pregnant women, caution in lactating women

Precautions & Warnings

  • Avoid long-term continuous therapy, especially in infants and children
  • Risk of atrophic changes on the face
  • Care needed to prevent entry into the eyes
  • Hazardous in psoriasis
  • Use of anti-microbial therapy for infected lesions

Use in Special Populations

Avoid long-term continuous therapy in infants and children under 12 years of age

Overdose Effects

Acute overdosage is unlikely, features of hypercortisolism in chronic over-dosage

Therapeutic Class

Other Topical corticosteroids

Storage Conditions

Below 30°C, protected from light and moisture, do not freeze

Related Brands