Proceptin 40 mg (Capsule (Enteric Coated))
Unit Price: ৳ 8.00 (3 x 10: ৳ 240.00)
Strip Price: ৳ 80.00
Medicine Details
Category | Details |
---|---|
Generic | Omeprazole |
Company | Beximco pharmaceuticals ltd |
Also available as |
Indications
- Treatment of Gastric and duodenal ulcer
- Treatment of NSAID-associated duodenal and gastric ulcer
- Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
- Treatment of Gastro-esophageal reflux disease
- Long-term management of acid reflux disease
- Treatment of Acid-related dyspepsia
- Treatment of Severe ulcerating reflux esophagitis
- Prophylaxis of acid aspiration during general anesthesia
- Treatment of Zollinger-Ellison syndrome
- Helicobacter pylori-induced peptic ulcer
Pharmacology
- Inhibitor of gastric acid secretion
- Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system in the gastric parietal cell
- Onset of antisecretory effect occurs within one hour
- Maximum effect occurs within two hours
- Inhibition of secretion lasts up to 72 hours
- Secretory activity returns gradually over 3 to 5 days after discontinuation
Dosage
- Oral administration for various conditions and durations
- IV Injection for prophylaxis of acid aspiration
- IV Injection for duodenal ulcer, gastric ulcer, or reflux oesophagitis
Administration
- Directions for use of IV Injection
- Directions for use of IV Infusion
- Uses for intravenous administration only
- Intravenous injection should be given slowly over 2 to 5 minutes
- Intravenous infusion over a period of 20-30 minutes or more
Interaction
- Decreased intragastric acidity affecting absorption of ketoconazole
- Metabolism via cytochrome P450 affecting elimination of diazepam, phenytoin, and warfarin
- Monitoring of patients receiving warfarin or phenytoin recommended
- Plasma concentrations increased during concomitant administration with clarithromycin
- No change in blood concentration of phenytoin during continuous treatment with phenytoin
- No change in coagulation time during continuous treatment with warfarin
Contraindications
- Known hypersensitivity to omeprazole
- Exclusion of malignancy suspicion before treatment
Side Effects
- Mild and reversible adverse reactions reported
- Skin rash, urticaria, and pruritus reported
- Photosensitivity, bullous eruption, erythema multiforme, angioedema, alopecia reported
- Diarrhoea and headache reported
- Gastrointestinal reactions including constipation, nausea/vomiting, flatulence, abdominal pain reported
Pregnancy & Lactation
- No adverse effects of Omeprazole on pregnancy or fetus/newborn child in epidemiological studies
- Omeprazole can be used during pregnancy
- No information available on passage into breast milk or effects on the neonate
- Breast-feeding should be discontinued if essential use of Omeprazole
Precautions & Warnings
- Avoid concomitant use with clopidogrel
- Increased risk for osteoporosis-related fractures observed with PPI therapy
- Atrophic gastritis noted occasionally in long-term treatment
- Concomitant use with methotrexate may lead to methotrexate toxicities
Therapeutic Class
- Proton Pump Inhibitor
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children
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