Temovate 0.05% (Cream)
10 gm tube: ৳ 58.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Clobetasol propionate |
| Company | Healthcare pharmaceuticals ltd |
| Also available as |
Indications
- Psoriasis (excluding widespread plaque psoriasis)
- Recalcitrant dermatoses
- Lichen planus
- Discoid lupus erythematosus
- Other skin conditions which do not respond satisfactorily to less potent steroids
Composition
- Clobetasol Propionate Cream: 0.05% w/w
- Clobetasol Propionate Ointment: 0.05% w/w
- Clobetasol Propionate Scalp Application: 0.05% w/w
- Clobetasol Propionate Shampoo: 0.05% w/w
- Clobetasol Propionate Lotion: 0.05% w/w
- Clobetasol Propionate Spray: 0.05% w/w
Pharmacology
- Very potent topical corticosteroid
- Anti-inflammatory
- Antipruritic
- Vasoconstrictive
- Inhibits late phase allergic reactions
- Reduces cytokine production
- Inhibits the metabolism of arachidonic acid
Dosage
- Adults, elderly and children over 1 year
- Cream and Ointment: Apply twice daily to affected skin areas
- Super-high potency topical corticosteroids
- Maximum weekly dose should not exceed 50 gm/week
- Scalp Solution: Apply once or twice daily to affected scalp areas
- Shampoo: Applied to dry scalp once a day, limited to 4 consecutive weeks
Administration
- Route of administration: Cutaneous
- Creams are appropriate for moist or weeping surfaces
- Ointments are appropriate for dry, lichenified or scaly lesions
Interaction
- Co-administered drugs that can inhibit CYP3A4 may increase systemic exposure
Contraindications
- Rosacea, acne vulgaris, perioral dermatitis
- Hypersensitivity to the preparation
- Not indicated for primarily infected skin lesions caused by fungi or bacteria
- Dermatoses in children under one year of age
Side Effects
- Prolonged use may result in systemic absorption
- Local atrophic changes in the skin
- Pustular form of psoriasis
- Pigmentation changes
- Exacerbation of symptoms
Pregnancy & Lactation
- Limited data in pregnant women
- Topical administration to pregnant animals can cause foetal abnormalities
- Use during pregnancy and lactation should be considered based on benefit-risk assessment
- Unknown excretion in human milk
Precautions & Warnings
- Long-term continuous therapy should be avoided, especially in infants and children
- Atrophic changes may occur, particularly on the face
- Care needed to avoid entry into the eyes
- Hazardous in psoriasis for several reasons
- Appropriate anti-microbial therapy should be used when treating infected lesions
Use in Special Populations
- Long-term continuous therapy should be avoided in infants and children under 12 years of age
Overdose Effects
- Acute overdosage is very unlikely to occur
- Chronic over-dosage or misuse may lead to features of hypercortisolism
Therapeutic Class
- Other Topical corticosteroids
Storage Conditions
- Keep below 30°C temperature
- Protected from light and moisture
- Do not freeze