Nyclobate NN (0.5 mg+5 mg+1 Lac IU)/gm (Ointment)

10 gm tube: ৳ 50.00

Medicine Details

Category Details
Generic Clobetasol propionate neomycin sulphate nystatin
Company Incepta pharmaceuticals ltd
Also available as
Nyclobate nn 05 mg cream

Indications

  • Treatment of recalcitrant eczemas
  • Neurodermatoses
  • Treatment of psoriasis with bacterial or fungal infection
  • Treatment of other inflammatory conditions

Pharmacology

  • Corticosteroid for severe inflammatory skin disorders
  • Antibiotic for bacterial infections
  • Antifungal for fungal and yeast infections
  • Mechanism of action of Clobetasol Propionate
  • Mechanism of action of Neomycin Sulphate
  • Mechanism of action of Nystatin

Dosage & Administration

  • Dosage for adults
  • Enhancement of anti-inflammatory effect
  • Caution for elderly patients
  • Dosage for children
  • Absorption in very young children

Interaction

  • Intensification of respiratory depressant effects
  • Systemic exposure to Neomycin Sulphate
  • Drug interactions with Clobetasol Propionate
  • Drug interactions with Nystatin

Contraindications

  • Rosacea
  • Acne vulgaris
  • Perioral dermatitis
  • Primary cutaneous viral infection
  • Hypersensitivity

Side Effects

  • Systemic absorption leading to hypercortisolism
  • Local atrophic changes in the skin
  • Pigmentation changes
  • Hypertrichosis
  • Prolonged use in infants and children

Pregnancy & Lactation

  • Effect of topically applied Neomycin in pregnancy and lactation
  • Maternal blood and placental crossing
  • Use of Clobetasol Propionate in lactating mothers

Precautions & Warnings

  • Avoidance of long-term continuous topical therapy
  • Adrenal suppression
  • Care when applying to the eyelids
  • Avoiding entry into the eye
  • Washing eye if it enters

Overdose Effects

  • Unlikelihood of acute overdosage
  • Features of hypercortisolism with chronic overdosage
  • Discontinuation of topical steroids

Therapeutic Class

  • Clobetasol / Clobetasone & Combined Preparations

Storage Conditions

  • Temperature storage
  • Protection from freezing
  • Safety precautions for children

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