Xenoderm (0.5 mg+5 mg+1 Lac IU)/gm (Ointment)
30 gm tube: ৳ 150.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Clobetasol propionate neomycin sulphate nystatin |
| Company | Unimed unihealth pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of recalcitrant eczemas
- Neurodermatoses
- Psoriasis with secondary bacterial or fungal infection
- Treatment of other inflammatory conditions
Pharmacology
- Clobetasol Propionate - very potent corticosteroid
- Neomycin Sulphate - aminoglycoside antibiotic
- Nystatin - antifungal
- Mechanism of topical steroids like Clobetasol
- Mechanism of action for Neomycin
- Mechanism of action for Nystatin
Dosage & Administration
- Adult dosage and application instructions
- Enhancement of anti-inflammatory effect with occlusion
- Caution for elderly patients
- Usage instructions for children and contraindication for neonates and infants
Interaction
- Interaction of Neomycin Sulphate with neuromuscular blocking agents
- Expected systemic exposure and minimal drug interactions with Neomycin
- No hazardous interactions reported with Clobetasol Propionate or Nystatin
Contraindications
- Contraindications for rosacea, acne vulgaris, and perioral dermatitis
- Primary cutaneous viral infections
- Hypersensitivity to the preparation
Side Effects
- Systemic absorption and hypercortisolism risks
- Local atrophic changes in the skin with prolonged treatment
- Reports of pigmentation changes and hypertrichosis
- Potential effects in infants and children
Pregnancy & Lactation
- Neomycin crossing placenta and theoretical risk in pregnancy
- Limited safety information on Clobetasol Propionate in lactating mothers
Precautions & Warnings
- Avoiding long-term continuous topical therapy
- Adrenal suppression in infants and children
- Eye exposure precautions and glaucoma risk
- Thorough eye washing if entry occurs
Overdose Effects
- Unlikelihood of acute overdosage
- Features of hypercortisolism with chronic overdosage
- Gradual discontinuation of topical steroids in overdose situation
Therapeutic Class
- Clobetasol / Clobetasone & Combined Preparations
Storage Conditions
- Temperature storage instructions
- Avoiding freezing
- Keep out of reach of children