Prolok 40 mg/vial (IV Injection)
40 mg vial: ৳ 90.00
Medicine Details
Category | Details |
---|---|
Generic | Omeprazole |
Company | Ibn sina pharmaceuticals ltd |
Also available as |
Indications
- Gastric and duodenal ulcer
- NSAID-associated duodenal and gastric ulcer
- Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
- Gastro-esophageal reflux disease
- Long-term management of acid reflux disease
- Acid-related dyspepsia
- Severe ulcerating reflux esophagitis
- Prophylaxis of acid aspiration during general anesthesia
- Zollinger-Ellison syndrome
- Helicobacter pylori-induced peptic ulcer
Pharmacology
- Inhibitor of gastric acid secretion
- Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
- Onset of antisecretory effect occurs within one hour
- Maximum effect occurs within two hours
- Inhibition of secretion lasts up to 72 hours
- Gradual return of secretory activity over 3 to 5 days after discontinuation
Dosage
- Oral dosage for various conditions
- IV injection dosage for prophylaxis of acid aspiration, duodenal ulcer, gastric ulcer, reflux esophagitis, Zollinger-Ellison syndrome
Administration
- Directions for IV injection use
- Directions for IV infusion use
Interaction
- Can reduce absorption of ketoconazole
- Metabolized in the liver through cytochrome P450
- Can delay the elimination of diazepam, phenytoin, and warfarin
- Plasma concentrations increased during concomitant administration with clarithromycin
- No evidence of interaction with phenacetin, theophylline, caffeine, propranolol, metoprolol, cyclosporin, lidocaine, quinidine, estradiol, amoxycillin, antacids, piroxicam, diclofenac, naproxen
- Increased bioavailability of digoxin with simultaneous treatment
Contraindications
- Known hypersensitivity to omeprazole
- Suspicion of gastric ulcer should exclude the possibility of malignancy before treatment
Side Effects
- Skin rash, urticaria, pruritus
- Photosensitivity, bullous eruption, erythema multiforme, angioedema, alopecia
- Diarrhea, headache
- Constipation, nausea/vomiting, flatulence, abdominal pain
- Dry mouth, stomatitis, candidiasis
- Paraesthesia
- Dizziness, light headedness, feeling faint
- Somnolence, insomnia, vertigo
- Reversible mental confusion, agitation, depression, hallucinations
- Arthritic and myalgic symptoms
- Blurred vision, taste disturbance, peripheral edema, increased sweating, gynaecomastia
- Leucopenia, thrombocytopenia, agranulocytosis, pancytopenia
- Anaphylactic shock, malaise, fever, bronchospasm
- Encephalopathy in patients with pre-existing severe liver disease
- Hepatitis with or without jaundice, interstitial nephritis, hepatic failure
- Increases in liver enzymes
Pregnancy & Lactation
- Results from epidemiological studies indicate no adverse effects on pregnancy or on the health of the fetus/newborn child
- Omeprazole can be used during pregnancy
- No information available on the passage of omeprazole into breast milk or its effects on the neonate
- Discontinue breastfeeding if essential use of omeprazole is considered
Precautions & Warnings
- Avoid concomitant use with clopidogrel
- Observational studies suggest an increased risk for osteoporosis-related fractures with PPI therapy
- Atrophic gastritis noted occasionally in patients treated long-term with omeprazole
- Concomitant use with methotrexate may lead to methotrexate toxicities
Therapeutic Class
- Proton Pump Inhibitor
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children
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