Promezol 40 mg (Capsule (Enteric Coated))

Unit Price: ৳ 8.03 (3 x 10: ৳ 240.90)
Strip Price: ৳ 80.30

Medicine Details

Category Details
Generic Omeprazole
Company Sharif pharmaceuticals ltd
Also available as
Promezol 20 mg capsule

Indications

  • Treatment of gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer treatment
  • Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
  • Gastro-esophageal reflux disease treatment
  • Long-term management of acid reflux disease
  • Acid-related dyspepsia treatment
  • Severe ulcerating reflux esophagitis treatment
  • Prophylaxis of acid aspiration during general anesthesia
  • Zollinger-Ellison syndrome treatment
  • Helicobacter pylori-induced peptic ulcer treatment

Pharmacology

  • Inhibitor of gastric acid secretion
  • Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
  • Onset of antisecretory effect occurs within one hour
  • Maximum effect occurring within two hours
  • Inhibition of secretion lasts up to 72 hours

Dosage

  • Benign gastric and duodenal ulcer dosage
  • NSAID-associated duodenal or gastric ulcer dosage
  • Gastro-esophageal reflux disease dosage
  • Long-term management of acid reflux disease dosage
  • Acid-related dyspepsia dosage
  • Prophylaxis of acid aspiration dosage
  • Zollinger-Ellison syndrome dosage
  • Helicobacter pylori eradication regimen in peptic ulcer disease dosage
  • Paediatric use in severe ulcerating reflux esophagitis dosage
  • IV injection dosage

Administration

  • Direction for use of IV Injection
  • Direction for use of IV Infusion

Interaction

  • Decreased intragastric acidity affecting ketoconazole absorption
  • Metabolism through cytochrome P450 affecting diazepam, phenytoin, and warfarin elimination
  • Increased plasma concentrations during concomitant administration
  • No evidence of interaction with phenacetin, theophylline, caffeine, propranolol, metoprolol, cyclosporin, lidocaine, quinidine, estradiol, amoxicillin, or antacids
  • No effect on absorption by alcohol or food
  • Increased bioavailability of digoxin during simultaneous treatment with Promezol

Contraindications

  • Known hypersensitivity

Side Effects

  • Mild and reversible adverse reactions
  • Skin rash, urticaria, and pruritus
  • Photosensitivity, bullous eruption, and erythema multiforme
  • Diarrhoea and headache
  • Gastrointestinal reactions such as constipation, nausea/vomiting, flatulence, and abdominal pain
  • Dizziness, lightheadedness, and feeling faint
  • Paraesthesia
  • Somnolence, insomnia, and vertigo
  • Reversible mental confusion, agitation, depression, and hallucinations
  • Arthritic and myalgic symptoms
  • Blurred vision, taste disturbance, peripheral oedema, increased sweating, gynaecomastia, and leucopenia
  • Thrombocytopenia, agranulocytosis, pancytopenia, anaphylactic shock, malaise, and fever
  • Bronchospasm, encephalopathy, hepatitis, interstitial nephritis, and hepatic failure
  • Increases in liver enzymes

Pregnancy & Lactation

  • No adverse effects on pregnancy or the health of the fetus/newborn child
  • Can be used during pregnancy
  • No information available on the passage into breast milk or its effects on the neonate
  • Breastfeeding discontinuation recommended if essential use is considered
  • Safety and effectiveness not established in pediatric patients less than 18 years of age

Precautions & Warnings

  • Avoid concomitant use with clopidogrel
  • Increased risk for osteoporosis-related fractures
  • Atrophic gastritis in patients treated long-term
  • Concomitant use with methotrexate may lead to toxicities

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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