Propin 40 mg (Capsule (Enteric Coated))
Unit Price: ৳ 7.55 (20's pack: ৳ 151.00)
Medicine Details
Category | Details |
---|---|
Generic | Omeprazole |
Company | Hallmark pharmaceuticals ltd |
Also available as |
Indications
- Gastric and duodenal ulcer
- NSAID-associated duodenal and gastric ulcer
- Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
- Gastro-esophageal reflux disease
- Long-term management of acid reflux disease
- Acid-related dyspepsia
- Severe ulcerating reflux esophagitis
- Prophylaxis of acid aspiration during general anesthesia
- Zollinger-Ellison syndrome
- Helicobacter pylori-induced peptic ulcer
Pharmacology
- Inhibitor of gastric acid secretion
- Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
- Onset of antisecretory effect within one hour
- Maximum effect within two hours
- Inhibition of secretion lasts up to 72 hours
- Gradual return of secretory activity over 3 to 5 days after discontinuation
Dosage
- Oral administration for various conditions and durations
- Maintenance doses for recurrent duodenal ulcer
- IV Injection for prophylaxis of acid aspiration, duodenal ulcer, gastric ulcer, reflux oesophagitis, Zollinger-Ellison syndrome
- IV Infusion for appropriate conditions and durations
- Directions for reconstitution and administration
Administration
- IV injection for intravenous administration only
- Slow intravenous injection for IV Injection
- Intravenous infusion over a period of 20-30 minutes or more for IV Infusion
- Specific instructions for reconstitution and usage
Interaction
- Decreased intragastric acidity affecting the absorption of other medications
- Metabolism through cytochrome P450 impacting the elimination of certain drugs
- Monitoring and potential dose adjustment for medications like warfarin and phenytoin
- Plasma concentration changes during concomitant administration of certain drugs
- Impact on absorption of specific drugs
- Increased bioavailability of digoxin due to increased intragastric pH
Contraindications
- Known hypersensitivity to Omeprazole
- Need to exclude possibility of malignancy in suspected gastric ulcer before treatment initiation
Side Effects
- Mild and reversible adverse reactions
- Skin rash, urticaria, pruritus
- Photosensitivity, bullous eruption, erythema multiforme, angioedema, alopecia
- Diarrhea, headache, constipation, nausea/vomiting, flatulence, abdominal pain
- Dry mouth, stomatitis, candidiasis
- Paraesthesia, dizziness, lightheadedness, feeling faint
- Somnolence, insomnia, vertigo
- Mental confusion, agitation, depression, hallucinations
- Arthritic and myalgic symptoms
- Various other isolated reported effects
Pregnancy & Lactation
- No adverse effects on pregnancy or fetus/newborn child based on studies
- Use during pregnancy possible
- No information available on passage into breast milk or effects on neonate
- Discontinuation of breastfeeding if essential use is considered
Precautions & Warnings
- Avoid concomitant use with clopidogrel
- Potential association with increased risk for osteoporosis-related fractures
- Occasional atrophic gastritis noted in long-term treatment
- Possible impact on methotrexate toxicities
Therapeutic Class
- Proton Pump Inhibitor
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children
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