Re 20 20 mg (Capsule (Enteric Coated))
Unit Price: ৳ 5.00 (40's pack: ৳ 200.00)
Medicine Details
Category | Details |
---|---|
Generic | Omeprazole |
Company | Reman drug laboratories ltd |
Also available as |
Indications
- Gastric and duodenal ulcer
- NSAID-associated duodenal and gastric ulcer
- Prophylaxis in patients with history of NSAID-associated duodenal and gastric ulcer
- Gastro-esophageal reflux disease
- Long-term management of acid reflux disease
- Acid-related dyspepsia
- Severe ulcerating reflux esophagitis
- Prophylaxis of acid aspiration during general anesthesia
- Zollinger-Ellison syndrome
- Helicobacter pylori-induced peptic ulcer
Pharmacology
- Inhibitor of gastric acid secretion
- Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
- Onset of antisecretory effect within one hour
- Maximum effect within two hours
- Inhibition of secretion lasts up to 72 hours
- Gradual return of secretory activity over 3 to 5 days after discontinuation
Dosage
- Benign gastric and duodenal ulcer: 20mg once daily for 4-8 weeks
- NSAID-associated duodenal or gastric ulcer: 20mg once daily for 4-8 weeks
- Gastro-esophageal reflux disease: 20mg once daily for 4-8 weeks
- Long-term management of acid reflux disease: 10-20mg daily
- Acid-related dyspepsia: 10-20mg once daily for 2-4 weeks
- Zollinger-Ellison syndrome: 20-120mg daily; 2 divided doses if daily dose is more than 80mg
- Helicobacter pylori eradication regimen: 20mg twice daily with antimicrobial agents
- Paediatric use in severe ulcerating reflux esophagitis: 10-40mg once daily for 4-12 weeks
Administration
- IV Injection for prophylaxis of acid aspiration: 40mg given slowly over 5 minutes
- IV Injection for duodenal ulcer, gastric ulcer or reflux esophagitis: 40mg once daily
- IV Injection for Zollinger-Ellison syndrome: 60mg daily; higher doses may be required
- IV Infusion over 20-30 minutes or more
Interaction
- Reduced absorption of ketoconazole during treatment
- Metabolised in the liver through cytochrome P450
- Potential delay in elimination of diazepam, phenytoin, and warfarin
- Increased plasma concentrations during concomitant administration with clarithromycin
- No evidence of interaction with phenacetin, theophylline, caffeine, propranolol, and more
Contraindications
- Known hypersensitivity to omeprazole
- Suspicion of gastric ulcer without excluding possibility of malignancy
Side Effects
- Skin rash, urticaria, pruritus, photosensitivity
- Diarrhea, headache, constipation, nausea/vomiting
- Dry mouth, stomatitis, candidiasis, paraesthesia
- Dizziness, lightheadedness, somnolence, insomnia
- Reversible mental confusion, agitation, depression, hallucinations
- Arthritic and myalgic symptoms, blurred vision, taste disturbance
- Peripheral edema, increased sweating, leucopenia, thrombocytopenia
- Hepatitis, interstitial nephritis, hepatic failure, increases in liver enzymes
Pregnancy & Lactation
- No adverse effects on pregnancy or fetus/newborn child
- Safe for use during pregnancy
- No information on passage into breast milk or effects on neonate
- Discontinue breast-feeding if essential use of omeprazole
Precautions & Warnings
- Avoid concomitant use with clopidogrel
- Potential association with increased risk for osteoporosis-related fractures
- Atrophic gastritis noted in long-term treatment
- Concomitant use with methotrexate may lead to toxicities
Therapeutic Class
- Proton Pump Inhibitor
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children
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