G-Co-Aspirin 75 mg+75 mg (Tablet)

Unit Price: ৳ 5.00 (3 x 10: ৳ 150.00)
Strip Price: ৳ 50.00

Medicine Details

Category Details
Generic Clopidogrel aspirin
Company Gonoshasthaya pharma ltd

Indications

  • Reduces the rate of Myocardial Infarction (MI) and Stroke in patients with non-ST-segment elevation ACS
  • Reduces the rate of MI and Stroke in patients with acute ST-segment elevation ACS
  • Indicated for patients with recent MI, recent Stroke, or established Peripheral Arterial Disease to reduce the rate of MI and Stroke

Pharmacology

  • Inhibits platelet activation and aggregation through irreversible binding of active metabolite to P2Y12 class of ADP receptors
  • Dose-dependent inhibition of platelet aggregation seen at 2 hours after single oral doses
  • Inhibits platelet aggregation by irreversible inhibition of platelet cyclooxygenase and generation of thromboxane A2

Dosage & Administration

  • Recommended daily dose of 75 mg once daily with or without food
  • Initiate with a single 300 mg loading dose for patients with acute coronary syndrome, then continue at 75 mg once daily

Interaction

  • Aspirin does not modify Clopidogrel-mediated inhibition of ADP-induced platelet aggregation
  • Clopidogrel potentiates the effect of aspirin on collagen-induced platelet aggregation
  • Co-administration of Clopidogrel with heparin has no effect on inhibition of platelet aggregation induced by Clopidogrel
  • NSAIDs and Clopidogrel should be co-administered with caution
  • Concomitant administration of Clopidogrel with warfarin should be undertaken with caution

Contraindications

  • Contraindicated in hypersensitivity to the drug substance or any component of the product
  • Contraindicated in active pathological bleeding such as peptic ulcer or intracranial hemorrhage

Side Effects

  • Generally well tolerated

Pregnancy & Lactation

  • Should be used during first and second trimesters only if clearly needed
  • Contraindicated during the third trimester
  • Unknown whether Clopidogrel is excreted in human breast milk
  • Aspirin is known to be excreted in human milk
  • Discontinue during breastfeeding

Precautions & Warnings

  • Prolongs the bleeding time
  • TTP has been reported rarely following use
  • Reye's syndrome may develop in individuals with chicken pox, influenza, or flu symptoms
  • Hypersensitivity reactions reported in patients receiving G-Co-Aspirin or history of hypersensitivity to other thienopyridines

Use in Special Populations

  • Should not be given to children, particularly those under 12 years, unless expected benefits outweigh possible risks
  • Aspirin may be a contributory factor in the causation of Reye’s syndrome in some children

Overdose Effects

  • Clopidogrel overdose may lead to bleeding complications
  • In moderate aspirin intoxication, dizziness, headache, tinnitus, confusion, and gastrointestinal symptoms may occur

Therapeutic Class

  • Anti-platelet drugs

Storage Conditions

  • Keep in a cool & dry place (below 30°C)
  • Protected from light & moisture
  • Keep out of the reach of children

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