Regerd 20 mg (Capsule (Enteric Coated))
Medicine Details
Category | Details |
---|---|
Generic | Omeprazole |
Company | Novatek pharmaceuticals ltd |
Also available as |
Title
Regerd
Categories
- Medicine
- Pharmaceutical
Description
Omeprazole, a substituted benzimidazole, is an inhibitor of gastric acid secretion. It inhibits gastric acid secretion by blocking hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system in the gastric parietal cell. After oral administration, the onset of the antisecretory effect occurs within one hour, with the maximum effect occurring within two hours and inhibition of secretion lasts up to 72 hours. When the drug is discontinued, secretory activity returns gradually, over 3 to 5 days.
Indications
- Gastric and duodenal ulcer
- NSAID-associated duodenal and gastric ulcer
- As prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
- Gastro-esophageal reflux disease
- Long-term management of acid reflux disease
- Acid-related dyspepsia
- Severe ulcerating reflux esophagitis
- Prophylaxis of acid aspiration during general anesthesia
- Zollinger-Ellison syndrome
- Helicobacter pylori-induced peptic ulcer
Dosage
- Benign gastric and duodenal ulcer: 20 mg once daily for 4 weeks in duodenal ulceration, 8 weeks in gastric ulceration
- NSAID-associated duodenal or gastric ulcer: 20 mg once daily for 4 weeks, continued for further 4 weeks if not fully healed
- Gastro-esophageal reflux disease: 20 mg once daily for 4 weeks, continued for further 4-8 weeks if not fully healed
Administration
Omeprazole IV infusion should be given as an intravenous infusion over a period of 20-30 minutes or more. The contents of one vial must be dissolved in 100 ml saline for infusion or 100 ml 5% Dextrose for infusion.
Interaction
- Decreased intragastric acidity may reduce absorption of ketoconazole
- Metabolized in the liver through cytochrome P450, can delay the elimination of diazepam, phenytoin, and warfarin
Contraindications
- Patients with known hypersensitivity to Omeprazole
- When gastric ulcer is suspected, the possibility of malignancy should be excluded before treatment with Omeprazole is instituted
Side Effects
- Skin rash, urticaria, and pruritus
- Diarrhoea and headache
- Other gastrointestinal reactions including constipation and nausea/vomiting
- Dizziness, somnolence, and insomnia
Pregnancy & Lactation
Results from three prospective epidemiological studies indicate no adverse effects of Omeprazole on pregnancy or on the health of the fetus/newborn child. Omeprazole can be used during pregnancy.
Precautions & Warnings
- Avoid concomitant use of clopidogrel and Regerd
- Observational studies suggest that proton pump inhibitor (PPI) therapy may be associated with an increased risk for osteoporosis-related fractures
Therapeutic Class
Proton Pump Inhibitor
Storage Conditions
Keep in a dry place away from light and heat. Keep out of the reach of children.
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