Clocard 75 mg (Tablet)
Unit Price: ৳ 11.00 (3 x 10: ৳ 330.00)
Strip Price: ৳ 110.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Clopidogrel bisulphate |
| Company | Aristopharma ltd |
Indications
- Reduce rate of myocardial infarction in non-ST-segment elevation ACS
- Reduce rate of stroke in non-ST-segment elevation ACS
- Reduce rate of myocardial infarction in acute ST-elevation myocardial infarction
- Reduce rate of stroke in recent MI, recent stroke, or established peripheral arterial disease
Pharmacology
- Prodrug
- Inhibits platelet activation and aggregation
- Irreversible binding to P2Y12 class of ADP receptors
- Dose-dependent inhibition of platelet aggregation
- Effects seen after 2 hours of single oral doses
- Steady state reached between Day 3 and Day 7
Dosage & Administration
- 300 mg oral loading dose for acute coronary syndrome
- 75 mg once daily orally for recent MI, recent stroke, or established peripheral arterial disease
- Oral administration with or without food
Interaction
- Increases risk of bleeding when used with NSAIDs, warfarin, SSRIs, SNRIs
- Avoid concomitant use with omeprazole or esomeprazole
- Increases plasma concentrations of Repaglinide when used together
Contraindications
- Hypersensitivity to the drug substance or any component
- Active pathological bleeding such as peptic ulcer or intracranial hemorrhage
Side Effects
- Common: Bleeding, Diarrhoea, gastrointestinal discomfort, haemorrhage, Skin reactions
- Rare: Acquired haemophilia, anaemia, angioedema, arthralgia, arthritis, bone marrow disorders
Pregnancy & Lactation
- Use during pregnancy only if clearly needed
- Unknown excretion in human breast milk
- Decision should consider importance of the drug to the mother
Precautions & Warnings
- Impaired metabolism by genetic variations in CYP2C19
- Risk of bleeding may increase
- Discontinuation increases risk of cardiovascular events
- May lead to Thrombotic Thrombocytopenic Purpura
- Hypersensitivity reactions reported
Use in Special Populations
- Safety and effectiveness not established in pediatric populations
- No dosage adjustment necessary in elderly patients
Overdose Effects
- May lead to bleeding complications
- Platelet transfusion may restore clotting ability
Therapeutic Class
- Anti-platelet drugs
Storage Conditions
- Keep below 30°C
- Dry place
- Protected from light
- Do not freeze
- Keep out of the reach of children