Regerd 40 mg (Capsule (Enteric Coated))
Medicine Details
Category | Details |
---|---|
Generic | Omeprazole |
Company | Novatek pharmaceuticals ltd |
Also available as |
Indications
- Gastric and duodenal ulcer
- NSAID-associated duodenal and gastric ulcer
- As prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
- Gastro-esophageal reflux disease
- Long-term management of acid reflux disease
- Acid-related dyspepsia
- Severe ulcerating reflux esophagitis
- Prophylaxis of acid aspiration during general anesthesia
- Zollinger-Ellison syndrome
- Helicobacter pylori-induced peptic ulcer
Pharmacology
Omeprazole, a substituted benzimidazole, is an inhibitor of gastric acid secretion. It inhibits gastric acid secretion by blocking hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system in the gastric parietal cell. After oral administration, the onset of the antisecretory effect occurs within one hour, with the maximum effect occurring within two hours and inhibition of secretion lasts up to 72 hours. When the drug is discontinued, secretory activity returns gradually, over 3 to 5 days.
Dosage
- Oral administration for different conditions and durations
- IV Injection for prophylaxis of acid aspiration, duodenal ulcer, gastric ulcer, reflux oesophagitis, and Zollinger-Ellison syndrome
Administration
Omeprazole is administered intravenously. Directions for IV injection and IV infusion are provided.
Interactions
Information on interactions with other medications, including ketoconazole, diazepam, phenytoin, warfarin, clarithromycin, etc.
Contraindications
Omeprazole is contraindicated in patients with known hypersensitivity to it. It should not be administered if gastric ulcer is suspected, without excluding the possibility of malignancy.
Side Effects
List of reported adverse reactions including skin rash, diarrhea, headache, constipation, nausea/vomiting, dizziness, mental confusion, arthritic and myalgic symptoms, liver enzyme increases, and more.
Pregnancy & Lactation
Results from epidemiological studies regarding Omeprazole's effects on pregnancy and newborn health. Recommendations for use during pregnancy and lactation.
Precautions & Warnings
Advisories against concomitant use of clopidogrel, potential risk of increased osteoporosis-related fractures, atrophic gastritis, and methotrexate toxicities when used with PPIs.
Therapeutic Class
Proton Pump Inhibitor
Storage Conditions
Keep in a dry place away from light and heat. Keep out of the reach of children.
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