Clotinil 75 mg (Tablet)
Unit Price: ৳ 11.00 (30's pack: ৳ 330.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Clopidogrel bisulphate |
| Company | Rephco pharmaceuticals ltd |
Indications
- Reduce rate of myocardial infarction
- Reduce rate of stroke
- Treatment for non-ST-segment elevation ACS
- Treatment for ST-elevation myocardial infarction (STEMI)
- Treatment for recent MI
- Treatment for recent stroke
- Treatment for established peripheral arterial disease
Pharmacology
- Prodrug
- Inhibits platelet activation
- Inhibits platelet aggregation
- Irreversible binding to P2Y12 class of ADP receptors
- Dose-dependent inhibition of platelet aggregation
- Time to onset of action: 2 hours
- Steady state reached between Day 3 and Day 7
Dosage & Administration
- 300 mg oral loading dose for acute coronary syndrome
- 75 mg once daily for recent MI, recent stroke, or established peripheral arterial disease
- Oral administration
- With or without food
Interaction
- Increased risk of bleeding with NSAIDs, warfarin, SSRIs, SNRIs
- Avoid concomitant use with CYP2C19 inhibitors
- Avoid concomitant use with Repaglinide
Contraindications
- Hypersensitivity to the drug substance or any component
- Active pathological bleeding
Side Effects
- Common: Bleeding, Diarrhoea, gastrointestinal discomfort, haemorrhage, Skin reactions
- Rare: Acquired haemophilia, anaemia, angioedema, arthralgia, arthritis, bone marrow disorders
Pregnancy & Lactation
- Use during pregnancy only if clearly needed
- Unknown excretion in human breast milk
Precautions & Warnings
- Metabolism impairment by genetic variations in CYP2C19
- Risk of increased bleeding
- Increased risk of cardiovascular events upon discontinuation
- Reported cases of Thrombotic Thrombocytopenic Purpura (TTP)
- Hypersensitivity reactions
Use in Special Populations
- Safety and effectiveness not established in pediatric populations
- No dosage adjustment necessary in elderly patients
Overdose Effects
- May lead to bleeding complications
- Platelet transfusion may restore clotting ability
Therapeutic Class
- Anti-platelet drugs
Storage Conditions
- Keep below 30°C temperature
- Keep in a dry place
- Protected from light
- Do not freeze
- Keep out of the reach of children