Roceptin 20 mg (Capsule (Enteric Coated))
Unit Price: ৳ 5.00 (10 x 10: ৳ 500.00)
Strip Price: ৳ 50.00
Medicine Details
Category | Details |
---|---|
Generic | Omeprazole |
Company | Desh pharmaceuticals ltd |
Also available as |
Indications
- Gastric and duodenal ulcer
- NSAID-associated duodenal and gastric ulcer
- Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
- Gastro-esophageal reflux disease
- Long-term management of acid reflux disease
- Acid-related dyspepsia
- Severe ulcerating reflux esophagitis
- Prophylaxis of acid aspiration during general anesthesia
- Zollinger-Ellison syndrome
- Helicobacter pylori-induced peptic ulcer
Pharmacology
- Inhibitor of gastric acid secretion
- Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
- Onset of antisecretory effect within one hour
- Maximum effect occurring within two hours
- Inhibition of secretion lasts up to 72 hours
- Gradual return of secretory activity over 3 to 5 days after discontinuation
Dosage
- 20 mg once daily for benign gastric and duodenal ulcer
- 10-20 mg daily for long-term management of acid reflux disease
- 40 mg once daily for prophylaxis of acid aspiration
- 20 mg twice daily for H. pylori eradication regimen in peptic ulcer disease
- 10-20 mg once daily for severe ulcerating reflux esophagitis (Child>1 year)
Administration
- IV Injection for prophylaxis of acid aspiration, duodenal ulcer, gastric ulcer, or reflux oesophagitis
- IV Infusion over a period of 20-30 minutes or more
- Reconstitution of Omeprazole IV infusion with saline or 5% Dextrose
- Avoid mixing or co-administration with any other drug in the same infusion set
Interaction
- Reduced absorption of ketoconazole during Roceptin treatment
- Metabolized in the liver through cytochrome P450
- Possible delay in the elimination of diazepam, phenytoin, and warfarin
- Increased plasma concentrations during concomitant administration with clarithromycin
- No evidence of interaction with phenacetin, theophylline, caffeine, propranolol, metoprolol, cyclosporin, lidocaine, quinidine, estradiol, amoxycillin, or antacids
- No impact on absorption by alcohol or food
Contraindications
- Known hypersensitivity to Omeprazole
- Suspected gastric ulcer with possibility of malignancy
Side Effects
- Skin rash, urticaria, and pruritus
- Photosensitivity, bullous eruption, and erythema multiforme
- Diarrhoea, headache, constipation, and nausea/vomiting
- Dry mouth, stomatitis, and candidiasis
- Paraesthesia, dizziness, and feeling faint
- Somnolence, insomnia, and vertigo
- Reversible mental confusion, agitation, and depression
- Arthritic and myalgic symptoms
- Blurred vision, taste disturbance, and peripheral oedema
- Increased sweating, gynaecomastia, and leucopenia
- Thrombocytopenia, agranulocytosis, and pancytopenia
- Anaphylactic shock, malaise, and fever
- Bronchospasm, encephalopathy, and hepatitis
- Increases in liver enzymes
Pregnancy & Lactation
- No adverse effects on pregnancy or fetus/newborn child
- Use during pregnancy possible
- Effect on breast milk and neonate unknown
- Discontinuation of breast-feeding if essential use of Omeprazole
Therapeutic Class
- Proton Pump Inhibitor
Storage Conditions
- Keep in a dry place away from light and heat
Precautions & Warnings
- Avoid concomitant use with clopidogrel
- Increased risk for osteoporosis-related fractures with PPI therapy
- Atrophic gastritis noted in patients treated long-term with Roceptin
- Concomitant use with methotrexate may lead to toxicities
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