Cantina 1% (Cream)
Medicine Details
| Category | Details |
|---|---|
| Generic | Clotrimazole topical |
| Company | Kemiko pharmaceuticals ltd |
Indications
- All dermatomycoses due to dermatophytes (e.g.Trichophyton species)
- All dermatomycoses due to yeasts (Candida species)
- Dermatomycoses due to moulds and other fungi
- Skin diseases showing superinfections with these fungi
- Interdigital mycoses (e.g. athlete's foot)
- Paronychias (associated with nail mycoses)
- Mycoses in skin folds
- Candida vulvitis
- Candida balanitis
- Pityriasis versicolor
- Erythrasma
Description
Cantina is a broad-spectrum antifungal agent that is used for the treatment of dermal infections caused by various species of pathogenic dermatophytes, yeasts, moulds and bacteroids. Cantina is also active against certain gram-positive bacteria especially Staphylococci and Tricomonas. Like other imidazoles, Cantina alters the permeability of fungal cell walls by interfering with cell wall lipids. At fungi static levels the main effect is inhibition of ergosterol synthesis but at higher concentrations there is an additional mechanism of membrane damage unrelated to sterol synthesis.
Pharmacology
- Act primarily by damaging the permeability barrier in the cell membrane of fungi
- Causes inhibition of ergosterol biosynthesis
- Inhibition of lanosterol 14-demethylase
- Depletion of intracellular calcium
- Blocking of calcium‐dependent potassium channels and voltage‐dependent calcium channels
Dosage & Administration
- Clotrimazole Cream: Thinly applied 2-3 times daily to the infected sites and rubbed in
- Clotrimazole topical solution: Applied sparingly to the affected areas and rub in gently, two or three times daily
- Recommended duration of treatment:
- Dermatomycoses: 3-4 weeks
- Candida vulvitis and Candida balanitis: 1-2 weeks
- Erythrasma and Pityriasis Versicolor: 3 weeks (approximately)
- Treatment for fungal infection of the feet: Continued for about 2 weeks beyond the disappearance of all signs of disease
Interaction
No information is available
Contraindications
Hypersensitivity to Clotrimazole
Side Effects
When applied topically, Cantina is well tolerated. With external application, systemic effects are not observed. Local irritation or burning sensation may occur in a very few cases but these symptoms are not considered harmful
Pregnancy & Lactation
Recommended that Clotrimazole should be used in pregnancy only when considered necessary by the physician
Therapeutic Class
Drugs for subcutaneous and mycoses, Topical Antifungal preparations
Storage Conditions
Keep below 25°C temperature, away from light & moisture. Keep out of the reach of children