Rome 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 5.00 (10 x 10: ৳ 500.00)
Strip Price: ৳ 50.00

Medicine Details

Category Details
Generic Omeprazole
Company Rephco pharmaceuticals ltd

Indications

  • Gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer
  • Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
  • Gastro-esophageal reflux disease
  • Long-term management of acid reflux disease
  • Acid-related dyspepsia
  • Severe ulcerating reflux esophagitis
  • Prophylaxis of acid aspiration during general anesthesia
  • Zollinger-Ellison syndrome
  • Helicobacter pylori-induced peptic ulcer

Pharmacology

  • Inhibitor of gastric acid secretion
  • Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
  • Onset of antisecretory effect within one hour
  • Maximum effect within two hours
  • Inhibition of secretion lasts up to 72 hours
  • Return of secretory activity within 3 to 5 days after discontinuation

Dosage

  • Dosage for benign gastric and duodenal ulcer
  • Dosage for NSAID-associated duodenal or gastric ulcer
  • Dosage for gastro-esophageal reflux disease
  • Dosage for long-term management of acid reflux disease
  • Dosage for acid-related dyspepsia
  • Dosage for prophylaxis of acid aspiration
  • Dosage for Zollinger-Ellison syndrome
  • Dosage for Helicobacter pylori eradication regimen in peptic ulcer disease
  • Pediatric use in severe ulcerating reflux esophagitis

Administration

  • Direction for use of IV Injection
  • Direction for use of IV Infusion
  • Caution for intravenous administration only
  • Reconstitution guidelines
  • Intravenous infusion over a specific period

Interaction

  • Impact on absorption of ketoconazole
  • Metabolism through cytochrome P450
  • Potential delay in elimination of diazepam, phenytoin, and warfarin
  • Monitoring of patients receiving warfarin or phenytoin
  • Plasma concentration variations during concomitant administration
  • No evidence of interaction with certain medications
  • Impact on intragastric pH

Contraindications

  • Known hypersensitivity to Omeprazole
  • Possibility of malignancy in suspected gastric ulcer

Side Effects

  • Mild and reversible adverse reactions
  • Skin rash, urticaria, pruritus
  • Photosensitivity, bullous eruption, erythema multiforme
  • Diarrhea, headache
  • Gastrointestinal reactions
  • Neurological symptoms
  • Mental confusion, agitation, depression
  • Arthritic and myalgic symptoms
  • Abnormal laboratory findings

Pregnancy & Lactation

  • No adverse effects on pregnancy and fetus/child health
  • Safe use during pregnancy
  • Unknown passage into breast milk
  • Consideration of discontinuing breastfeeding
  • Safety not established in pediatric patients

Precautions & Warnings

  • Avoid concomitant use with clopidogrel
  • Association with increased risk for osteoporosis-related fractures
  • Atrophic gastritis in long-term treatment
  • Potential for methotrexate toxicities

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Keep in a dry place
  • Away from light and heat
  • Keep out of the reach of children

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