Rome 20 mg (Capsule (Enteric Coated))
Unit Price: ৳ 5.00 (10 x 10: ৳ 500.00)
Strip Price: ৳ 50.00
Medicine Details
Category | Details |
---|---|
Generic | Omeprazole |
Company | Rephco pharmaceuticals ltd |
Indications
- Gastric and duodenal ulcer
- NSAID-associated duodenal and gastric ulcer
- Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
- Gastro-esophageal reflux disease
- Long-term management of acid reflux disease
- Acid-related dyspepsia
- Severe ulcerating reflux esophagitis
- Prophylaxis of acid aspiration during general anesthesia
- Zollinger-Ellison syndrome
- Helicobacter pylori-induced peptic ulcer
Pharmacology
- Inhibitor of gastric acid secretion
- Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
- Onset of antisecretory effect within one hour
- Maximum effect within two hours
- Inhibition of secretion lasts up to 72 hours
- Return of secretory activity within 3 to 5 days after discontinuation
Dosage
- Dosage for benign gastric and duodenal ulcer
- Dosage for NSAID-associated duodenal or gastric ulcer
- Dosage for gastro-esophageal reflux disease
- Dosage for long-term management of acid reflux disease
- Dosage for acid-related dyspepsia
- Dosage for prophylaxis of acid aspiration
- Dosage for Zollinger-Ellison syndrome
- Dosage for Helicobacter pylori eradication regimen in peptic ulcer disease
- Pediatric use in severe ulcerating reflux esophagitis
Administration
- Direction for use of IV Injection
- Direction for use of IV Infusion
- Caution for intravenous administration only
- Reconstitution guidelines
- Intravenous infusion over a specific period
Interaction
- Impact on absorption of ketoconazole
- Metabolism through cytochrome P450
- Potential delay in elimination of diazepam, phenytoin, and warfarin
- Monitoring of patients receiving warfarin or phenytoin
- Plasma concentration variations during concomitant administration
- No evidence of interaction with certain medications
- Impact on intragastric pH
Contraindications
- Known hypersensitivity to Omeprazole
- Possibility of malignancy in suspected gastric ulcer
Side Effects
- Mild and reversible adverse reactions
- Skin rash, urticaria, pruritus
- Photosensitivity, bullous eruption, erythema multiforme
- Diarrhea, headache
- Gastrointestinal reactions
- Neurological symptoms
- Mental confusion, agitation, depression
- Arthritic and myalgic symptoms
- Abnormal laboratory findings
Pregnancy & Lactation
- No adverse effects on pregnancy and fetus/child health
- Safe use during pregnancy
- Unknown passage into breast milk
- Consideration of discontinuing breastfeeding
- Safety not established in pediatric patients
Precautions & Warnings
- Avoid concomitant use with clopidogrel
- Association with increased risk for osteoporosis-related fractures
- Atrophic gastritis in long-term treatment
- Potential for methotrexate toxicities
Therapeutic Class
- Proton Pump Inhibitor
Storage Conditions
- Keep in a dry place
- Away from light and heat
- Keep out of the reach of children
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