Romilok 20 mg (Capsule (Enteric Coated))
Unit Price: ৳ 4.00 (60's pack: ৳ 240.00)
Medicine Details
Category | Details |
---|---|
Generic | Omeprazole |
Company | Reliance pharmaceuticals ltd |
Indications
- Gastric and duodenal ulcers
- NSAID-associated duodenal and gastric ulcers
- Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcers
- Gastro-esophageal reflux disease
- Long-term management of acid reflux disease
- Acid-related dyspepsia
- Severe ulcerating reflux esophagitis
- Prophylaxis of acid aspiration during general anesthesia
- Zollinger-Ellison syndrome
- Helicobacter pylori-induced peptic ulcer
Pharmacology
- Inhibitor of gastric acid secretion
- Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
- Onset of antisecretory effect within one hour
- Maximum effect within two hours
- Inhibition of secretion lasts up to 72 hours
Dosage
- 20 mg once daily for benign gastric and duodenal ulcers
- 40 mg once daily in severe or recurrent cases
- Maintenance dose for recurrent duodenal ulcer is 20 mg once daily
- 20 mg once daily for 4-8 weeks in gastro-esophageal reflux disease
- 10-20 mg daily for long-term management of acid reflux disease
- 10-20 mg once daily for 2-4 weeks in acid-related dyspepsia
- 40 mg on the preceding evening, then 40 mg 2-6 hours before surgery for prophylaxis of acid aspiration
- 20 mg twice daily for helicobacter pylori eradication regimen in peptic ulcer disease
Administration
- IV Injection: Given slowly over a period of 5 minutes as prophylaxis of acid aspiration
- IV Infusion: Given over a period of 20-30 minutes or more
Interaction
- Decreased intragastric acidity may reduce the absorption of ketoconazole
- Metabolized in the liver through cytochrome P450
- May delay the elimination of diazepam, phenytoin, and warfarin
- Plasma concentrations of Romilok and clarithromycin are increased during concomitant administration
Contraindications
- Known hypersensitivity to Omeprazole
- Suspicion of gastric ulcer while malignancy is not excluded
Side Effects
- Skin rash, urticaria, pruritus
- Photosensitivity, bullous eruption, erythema multiforme
- Diarrhea, headache
- Constipation, nausea/vomiting, flatulence, abdominal pain
- Dry mouth, stomatitis, candidiasis
Pregnancy & Lactation
- Results from studies indicate no adverse effects on pregnancy or on the health of the fetus/newborn child
- No information available on the passage into breast milk or its effects on the neonate
Precautions & Warnings
- Avoid concomitant use of clopidogrel and Romilok
- Increased risk for osteoporosis-related fractures
- Atrophic gastritis noted occasionally in gastric corpus biopsies from long-term use
Therapeutic Class
- Proton Pump Inhibitor
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children
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