Sectil 40 mg (Capsule (Enteric Coated))

Unit Price: ৳ 7.00 (40's pack: ৳ 280.00)

Medicine Details

Category Details
Generic Omeprazole
Company Cosmic pharma ltd
Also available as
Sectil 20 mg capsule

Indications

  • Gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer
  • Prophylaxis in patients with a history of NSAID-associated ulcers
  • Gastro-esophageal reflux disease
  • Long-term management of acid reflux disease
  • Acid-related dyspepsia
  • Severe ulcerating reflux esophagitis
  • Prophylaxis of acid aspiration during general anesthesia
  • Zollinger-Ellison syndrome
  • Helicobacter pylori-induced peptic ulcer

Pharmacology

  • Inhibitor of gastric acid secretion
  • Gastric parietal cell
  • Hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
  • Onset of antisecretory effect within one hour
  • Maximum effect within two hours
  • Inhibition of secretion lasts up to 72 hours
  • Gradual return of secretory activity over 3 to 5 days after discontinuation

Dosage

  • 20 mg once daily for 4-8 weeks in benign gastric and duodenal ulcer treatment
  • 20 mg once daily for 4 weeks in NSAID-associated duodenal or gastric ulcer treatment
  • 10-20 mg daily for long-term management of acid reflux disease
  • 40 mg on the preceding evening and 2-6 hours before surgery for prophylaxis of acid aspiration
  • Initially 60 mg once daily for Zollinger-Ellison syndrome
  • 20 mg twice daily in helicobacter pylori eradication regimen in peptic ulcer disease
  • 10-20 mg once daily for 4-12 weeks for severe ulcerating reflux esophagitis in pediatric use

Administration

  • Intravenous administration only for Omeprazole lyophilized powder and water for injection
  • IV injection given slowly over a period of 5 minutes
  • IV infusion given over a period of 20-30 minutes
  • Reconstituted solution should be used within specific time frames and not mixed with other drugs in the same infusion set

Interaction

  • Decreased intragastric acidity affecting ketoconazole absorption
  • Metabolism through cytochrome P450 affecting elimination of diazepam, phenytoin, and warfarin
  • Plasma concentrations of Omeprazole and clarithromycin increased during concomitant administration
  • No evidence of interaction with phenacetin, theophylline, caffeine, or antacids
  • Increased bioavailability of digoxin with simultaneous treatment with Omeprazole

Contraindications

  • Known hypersensitivity to Omeprazole
  • Exclusion of malignancy possibility in suspected gastric ulcer before treatment initiation

Side Effects

  • Skin rash, urticaria, and pruritus
  • Photosensitivity, bullous eruption, and erythema multiforme
  • Diarrhea, headache, constipation, and nausea/vomiting
  • Dry mouth, stomatitis, and candidiasis
  • Paraesthesia, dizziness, and light headedness
  • Reversible mental confusion, agitation, and depression
  • Arthritic and myalgic symptoms
  • Increases in liver enzymes

Pregnancy & Lactation

  • No adverse effects of Omeprazole on pregnancy or fetus/newborn child found in prospective epidemiological studies
  • Use during pregnancy can be considered
  • No information available on passage into breast milk or effects on neonate
  • Discontinuation of breastfeeding advised if essential use of Omeprazole is considered

Precautions & Warnings

  • Avoid concomitant use of clopidogrel and Omeprazole
  • Possible increased risk for osteoporosis-related fractures with PPI therapy
  • Atrophic gastritis noted occasionally with long-term use
  • Concomitant use with methotrexate may lead to toxicities

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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