Som 20 mg (Capsule (Enteric Coated))
Unit Price: ৳ 4.00 (60's pack: ৳ 240.00)
Medicine Details
Category | Details |
---|---|
Generic | Omeprazole |
Company | Marker pharma ltd |
Indications
- Gastric and duodenal ulcer
- NSAID-associated duodenal and gastric ulcer
- Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
- Gastro-esophageal reflux disease
- Long-term management of acid reflux disease
- Acid-related dyspepsia
- Severe ulcerating reflux esophagitis
- Prophylaxis of acid aspiration during general anesthesia
- Zollinger-Ellison syndrome
- Helicobacter pylori-induced peptic ulcer
Pharmacology
- Inhibitor of gastric acid secretion
- Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
- Onset of antisecretory effect within one hour of oral administration
- Maximum effect occurring within two hours
- Inhibition of secretion lasts up to 72 hours
- Secretory activity returns gradually over 3 to 5 days after discontinuation
Dosage
- Oral administration for different conditions and durations
- IV injection for different conditions and doses
Administration
- Direction for use of IV Injection
- Direction for use of IV Infusion
Interaction
- Decreased intragastric acidity affecting absorption of ketoconazole
- Metabolism through cytochrome P450 affecting elimination of diazepam, phenytoin, and warfarin
Contraindications
- Known hypersensitivity to omeprazole
- Suspected gastric ulcer with possibility of malignancy
Side Effects
- Skin rash, urticaria, pruritus
- Photosensitivity, bullous eruption, erythema multiforme, angioedema, alopecia
- Diarrhea, headache
- Constipation, nausea/vomiting, flatulence, abdominal pain
- Dry mouth, stomatitis, candidiasis
- Paraesthesia, dizziness, lightheadedness, feeling faint
- Somnolence, insomnia, vertigo
- Reversible mental confusion, agitation, depression, hallucinations
- Arthritic and myalgic symptoms
- Blurred vision, taste disturbance, peripheral edema, increased sweating, gynaecomastia
- Leucopenia, thrombocytopenia, agranulocytosis, pancytopenia, anaphylactic shock, malaise, fever
- Hepatitis with or without jaundice, interstitial nephritis, hepatic failure
- Increases in liver enzymes
Pregnancy & Lactation
- Results from prospective epidemiological studies
- No adverse effects of Omeprazole on pregnancy or on the health of the fetus/newborn child
- Safe use during pregnancy
- No information available on the passage of Omeprazole into breast milk or its effects on the neonate
- Discontinuation of breastfeeding if essential use of Omeprazole is considered
Precautions & Warnings
- Avoid concomitant use of clopidogrel and Som
- Increased risk for osteoporosis-related fractures with PPI therapy
- Atrophic gastritis in long-term treatment
- Concomitant use with methotrexate may lead to toxicities
Therapeutic Class
- Proton Pump Inhibitor
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children