Neoclomide 1 gm/vial (IV Infusion)

1 gm vial: ৳ 800.00

Medicine Details

Category Details
Generic Cyclophosphamide
Company Healthcare pharmaceuticals ltd
Also available as
Neoclomide 50 mg tablet Neoclomide 200 mg injection Neoclomide 500 mg injection

Indications

  • Malignant lymphomas
  • Hodgkin's disease
  • Leukemias
  • Mycosis fungoides
  • Neuroblastoma
  • Adenocarcinoma of the ovary
  • Retinoblastoma
  • Carcinoma of the breast
  • Minimal Change Nephrotic Syndrome

Pharmacology

  • Biotransformation in liver
  • Active alkylating metabolites
  • Interfere with growth of malignant cells
  • Cross-linking of tumor cell DNA
  • High bioavailability after oral administration
  • Elimination in urine
  • Plasma protein binding
  • Metabolites in plasma and urine

Dosage & Administration

  • Intravenous administration
  • 40-50 mg/kg initial dose
  • Oral dosing range of 1-5 mg/kg/day
  • Dosage adjustment based on leukocyte count
  • Dialyzable
  • No consistent evidence for renal impairment dosage modification
  • Specific dosage for Minimal Change Nephrotic Syndrome in children

Interaction

  • Metabolism and leukopenic activity affected by phenobarbital
  • Possible combined drug actions
  • Inhibition of cholinesterase activity potentiation
  • Alerting anesthesiologist after Neoclomide treatment

Contraindications

  • Severely depressed bone marrow function
  • Previous hypersensitivity

Side Effects

  • Nausea and vomiting
  • Anorexia
  • Abdominal discomfort
  • Diarrhea
  • Hemorrhagic colitis
  • Alopecia
  • Skin rash
  • Leukopenia
  • Thrombocytopenia
  • Anemia
  • Hemorrhagic ureteritis
  • Renal tubular necrosis
  • Interstitial pneumonitis
  • Anaphylactic reactions
  • SIADH
  • Malaise and asthenia

Pregnancy & Lactation

  • Pregnancy Category D
  • Excretion in breast milk
  • Consideration for discontinuing nursing

Precautions & Warnings

  • Special attention in presence of certain conditions
  • Leukopenia
  • Thrombocytopenia
  • Tumor cell infiltration of bone marrow
  • Impaired hepatic function
  • Impaired renal function

Use in Special Populations

  • Similar safety profile in pediatric patients
  • Insufficient data for patients aged 65 and older
  • Increased susceptibility of elderly to toxicities

Overdose Effects

  • No specific antidote
  • Supportive measures for managing overdose

Therapeutic Class

  • Cytotoxic Chemotherapy

Storage Conditions

  • Temperature not exceeding 25°C
  • Dry place
  • Protected from light and moisture
  • No freezing

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