Danlene 25 mg (Capsule)
Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)
Strip Price: ৳ 100.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Dantrolene sodium |
| Company | Incepta pharmaceuticals ltd |
Indications
- Chronic Spasticity control
- Treatment of clinical spasticity resulting from upper motor neuronal disorders
- Patients with reversible spasticity
- Improvement in painful and/or disabling spasticity
- Malignant Hyperthermia prevention
Pharmacology
- Relaxation of skeletal muscle
- Effect on excitation-contraction coupling
- Interference with release of Ca++ from sarcoplasmic reticulum
Dosage & Administration
- Gradual titration schedule for adults
- Gradual titration schedule for pediatric patients
- Maximum accepted dosage for adults
- Dosing for Malignant Hyperthermia prevention
- Post-crisis follow-up dosing
Interaction
- Drowsiness with therapy
- Concomitant administration with CNS depressants
- Hepatotoxicity in women over 35 with estrogen therapy
Contraindications
- Active hepatic disease such as hepatitis and cirrhosis
Side Effects
- Drowsiness
- Dizziness
- Weakness
- General malaise
- Fatigue
- Diarrhea (severe cases may necessitate withdrawal)
Pregnancy & Lactation
- Pregnancy Category C
- Use only if potential benefit justifies potential risk to fetus
- Not for use in nursing mothers
Precautions & Warnings
- Potential for liver damage in long-term use
- Caution against driving or hazardous occupations
- Possibility of photosensitivity reaction
- Need for liver function studies at start of therapy
- Caution in concomitant administration of tranquilizing agents
- Liver function testing during therapy
- Caution in patients with impaired pulmonary function
- Caution in patients with severely impaired cardiac function
- Caution in patients with history of previous liver disease or dysfunction
- Caution in females and patients over 35 years of age
Use in Special Populations
- Long-term safety in pediatric patients under 5 years not established
Therapeutic Class
- Centrally acting Skeletal Muscle Relaxants
Storage Conditions
- Store in cool and dry place, protected from light