Dapazin 10 mg (Tablet)
Unit Price: ৳ 30.00 (1 x 14: ৳ 420.00)
Strip Price: ৳ 420.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Dapagliflozin propanediol |
| Company | Concord pharmaceuticals ltd |
| Also available as |
Indications
- Adjunct to diet and exercise
- Improve glycemic control
- Type 2 diabetes mellitus
Pharmacology
- Inhibitor of Sodium-glucose co-transporter 2 (SGLT2)
- Reduces reabsorption of filtered glucose
- Lowers renal threshold for glucose
- Increases urinary glucose excretion
Dosage & Administration
- Recommended starting dose of 5 mg once daily
- Can be taken with or without food
- Dose can be increased to 10 mg once daily if needed
- Assessment of renal function recommended prior to initiation
- No established safety and efficacy in children and adolescents
Interaction
- May add to the diuretic effect of thiazide and loop diuretics
- Increase the risk of dehydration and hypotension
- May interact with insulin, sulphonylureas, antihypertensives, pioglitazone, ACE inhibitors, angiotensin II antagonists, GLP-1 agonists, valsartan, rifampin, mefenamic acid
Contraindications
- Known hypersensitivity to Dapagliflozin
- Severe renal impairment
- End-stage renal diseases or patients on dialysis
Side Effects
- Hypotension
- Ketoacidosis
- Acute kidney injury
- Impairment in renal function
- Genital mycotic infections
- Increases in low-density lipoprotein cholesterol (LDL-C)
- Nasopharyngitis
- Urinary tract infection
- Bladder cancer
Pregnancy & Lactation
- Pregnancy category C
- Use only if potential benefit justifies potential risk
- Not to be used during lactation
Precautions & Warnings
- Assess volume status and correct hypovolemia before initiation
- Monitor signs and symptoms of hypotension during therapy
- Monitor renal function during therapy
- Consider lower dose of insulin or insulin secretagogue to reduce risk of hypoglycemia
- Caution in patients with a prior history of bladder cancer
- No clinical studies establishing macrovascular risk reduction
Therapeutic Class
- Sodium-glucose Cotransporter-2 (SGLT2) Inhibitors
Storage Conditions
- Store in a cool place below 30°C
- Store in a dry place protected from light
- Keep away from the reach of children