Daxetin 60 mg (Tablet)

Unit Price: ৳ 50.00 (2 x 4: ৳ 400.00)
Strip Price: ৳ 200.00

Medicine Details

Category Details
Generic Dapoxetine hydrochloride
Company Aci limited
Also available as

Indications

  • Treatment of premature ejaculation in men 18 to 64 years of age
  • Ejaculation with minimal sexual stimulation before, on, or shortly after penetration
  • Marked personal distress or interpersonal difficulty as a consequence of PE
  • Poor control over ejaculation

Pharmacology

  • Inhibition of neuronal reuptake of serotonin
  • Potentiation of neurotransmitter's action
  • Rapid absorption with maximum plasma concentrations occurring 1-2 hours after intake
  • Absolute bioavailability is 42%
  • Extensive metabolism to multiple metabolites primarily through various biotransformational pathways
  • Rapid distribution with a mean steady state volume of distribution of 162 L
  • Terminal half-life is approximately 19 hours

Dosage & Administration

  • Recommended starting dose for adult men is 30 mg
  • Maximum recommended dosing frequency is once every 24 hours
  • Dose may be increased to the maximum recommended dose of 60 mg if 30 mg is insufficient
  • Not recommended for use in individuals below 18 years of age
  • Caution advised in patients with mild or moderate renal impairment
  • Contraindicated in patients with moderate and severe hepatic impairment

Interaction

  • Concomitant administration with CNS active medicinal products
  • Prescribed with caution in patients who use PDE5 inhibitors
  • Prescribed with caution in patients who use alpha adrenergic receptor antagonists
  • Caution advised when used in patients taking Warfarin chronically
  • Concomitant use of alcohol could increase the chance or severity of adverse reactions

Contraindications

  • Known hypersensitivity to Dapoxetine Hydrochloride
  • Significant pathological cardiac conditions
  • Concomitant treatment with monoamine oxidase inhibitors
  • Concomitant treatment with serotonin reuptake inhibitors
  • Not recommended within 14 days of discontinuing treatment with serotonergic medicinal/herbal products

Side Effects

  • Nausea
  • Dizziness
  • Dry mouth
  • Headache
  • Diarrhea
  • Insomnia
  • Low rates of sexual dysfunction

Pregnancy & Lactation

  • Not indicated for use by women
  • Not known if excreted through human breast milk

Precautions & Warnings

  • Not to be used in combination with recreational drugs
  • Avoid alcohol while taking Dapoxetine
  • Patients could experience syncope at any time during their treatment
  • An orthostatic test should be performed before initiating therapy
  • Caution advised in patients taking Dapoxetine with medicinal products known to affect platelet function
  • Prescribed with caution in patients who use PDE5 inhibitors
  • Not recommended in patients with a history of bleeding or coagulation disorders

Overdose Effects

  • No case of overdose reported
  • Symptoms of overdose with SSRIs include serotonin-mediated adverse reactions
  • No evidence of withdrawal syndrome

Therapeutic Class

  • Drugs for Erectile Dysfunction

Storage Conditions

  • Store below 30°C
  • Protect from light and moisture
  • Keep out of reach of children

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