Defzort 24 mg (Tablet)
Unit Price: ৳ 30.00 (5 x 4: ৳ 600.00)
Strip Price: ৳ 120.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Deflazacort |
| Company | Aci limited |
| Also available as |
Indications
- Anaphylaxis
- Asthma
- Rheumatoid arthritis
- Juvenile chronic arthritis
- Polymyalgia rheumatica
- Systemic lupus erythematosus
- Dermatomyositis
- Mixed connective tissue disease
- Polyartritis nodosa
- Sarcoidosis
- Pemphigus
- Bullous pemphigoid
- Pyoderma gangrenosum
- Minimal change nephrotic syndrome
- Acute interstitial nephritis
- Rheumatic carditis
- Ulcerative colitis
- Crohn's disease
- Uveitis
- Optic neuritis
- Autoimmune hemolytic anemia
- Idiopathic thrombocytopenic purpura
- Acute lymphatic leukemia
- Malignant lymphoma
- Multiple myeloma
- Immune suppression in transplantation
Pharmacology
Provides anti-inflammatory action by inhibiting Phospholipase A2 enzyme and decreases the release of certain chemicals in the immune system
Dosage & Administration
- Adults: For acute disorders: Up to 120 mg/day initially, Maintenance doses in most conditions are within the range of 3-18 mg/day
- Rheumatoid arthritis: Maintenance dose is usually within the range of 3-18 mg/day
- Bronchial asthma: High doses of 48-72 mg/day may be needed for acute attack, Maintenance doses should be titrated to the lowest effective dose
- Children: Doses usually lie in the range 0.25-1.5 mg/kg/day
- Deflazacort withdrawal should not be abrupt
Interaction
Metabolized in the liver, maintenance dose may need adjustment when co-administered with liver enzyme inducers or inhibitors
Contraindications
Hypersensitivity to any of the ingredients, Patients receiving live virus immunization
Side Effects
- GI disturbances
- Musculoskeletal issues
- Endocrine disturbances
- Neuropsychiatric issues
- Ophthalmic issues
- Fluid and electrolyte disturbances
- Susceptibility to infection
- Impaired healing
- Hypersensitivity reactions
- Skin atrophy
- Striae
- Telangiectasia
- Acne
- Myocardial rupture following recent Ml
- Thromboembolism
Pregnancy & Lactation
- Pregnancy: Corticosteroids may increase the risk of intrauterine growth retardation, should be prescribed only when benefits outweigh risks
- Nursing Mother: Doses of up to 50 mg daily unlikely to cause systemic effects in the infant, higher doses may lead to adrenal suppression in the infant
Precautions & Warnings
- Cardiac disease or congestive heart failure
- Hypertension
- Thromboembolic disorders
- Gastritis or oesophagitis
- Diverticulitis
- Ulcerative colitis
- Diabetes mellitus
- Osteoporosis
- Myasthenia gravis
- Renal insufficiency
- Emotional instability or psychotic tendency
- Epilepsy
- Liver failure
- Hypothyroidism
- Ocular herpes simplex
Use in Special Populations
- Hepatic Impairment: Blood levels may be increased, dose should be carefully monitored and adjusted to the minimum effective dose
- Renal Impairment: No special precautions necessary
- Elderly: No special precautions necessary, common adverse effects may have more serious consequences in old age
Therapeutic Class
Glucocorticoids
Storage Conditions
Store in a cool, dry place, protected from light and moisture, Keep out of the reach of children