Xalcort 24 mg (Tablet)
Unit Price: ৳ 30.00 (3 x 10: ৳ 900.00)
Strip Price: ৳ 300.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Deflazacort |
| Company | Beacon pharmaceuticals plc |
| Also available as |
Indications
- Anaphylaxis, asthma, severe hypersensitivity reactions
- Rheumatoid arthritis, juvenile chronic arthritis, polymyalgia rheumatica
- Systemic lupus erythematosus, dermatomyositis, mixed connective tissue disease
- Polyartritis nodosa, sarcoidosis
- Pemphigus, bullous pemphigoid, pyoderma gangrenosum
- Minimal change nephrotic syndrome, acute interstitial nephritis
- Rheumatic carditis
- Ulcerative colitis, Crohn's disease
- Uveitis, optic neuritis
- Autoimmune haemolytic anaemia, idiopathic thrombocytopenic purpura
- Acute and lymphatic leukaemia, malignant lymphoma, multiple myeloma
- Immune suppression in transplantation
Pharmacology
- Provides anti-inflammatory action
- Inhibits Phospholipase A2 enzyme
- Decreases release of certain chemicals in the immune system
Dosage & Administration
- Maintenance dose for adults: 3-18 mg/day
- Maintenance dose for children: 0.25-1.5 mg/kg/day
- Range for juvenile chronic arthritis maintenance dose: 0.25-1.0 mg/kg/day
- Range for nephrotic syndrome initial dose: 1.5 mg/kg/day
- Deflazacort withdrawal recommendations
Interaction
- Metabolized in the liver
- Recommendation for co-administration with liver enzyme inducers
- Recommendation for co-administration with liver enzyme inhibitors
Contraindications
- Hypersensitivity to any of the ingredients
- Patients receiving live virus immunization
Side Effects
- GI disturbances
- Musculoskeletal effects
- Endocrine effects
- Neuropsychiatric effects
- Ophthalmic effects
- Fluid and electrolyte disturbances
- Susceptibility to infection
- Impaired healing
- Hypersensitivity reactions
- Skin atrophy
- Striae
- Telangiectasia
- Acne
- Myocardial rupture following recent MI
- Thromboembolism
Pregnancy & Lactation
- Potential risk of intrauterine growth retardation
- Excretion of corticosteroids in breast milk
- Recommendation for prescription only when benefits outweigh risks
Precautions & Warnings
- Special caution for cardiac disease or congestive heart failure
- Necessary monitoring for salt and water retention
- Special caution for gastritis, oesophagitis, diverticulitis, ulcerative colitis
- Special caution for diabetes mellitus, osteoporosis, myasthenia gravis
- Special caution for emotional instability or psychotic tendency
- Special caution for liver failure, hypothyroidism, and cirrhosis
- Avoid in ocular herpes simplex
Use in Special Populations
- Increased blood levels in hepatic impairment
- May require careful monitoring and dosage adjustment in hepatic impairment
- No special precautions in renally impaired patients
- No special precautions in elderly patients
Therapeutic Class
- Glucocorticoids
Storage Conditions
- Store in a cool (below 25°C) and dry place
- Protected from light & moisture
- Keep out of the reach of children