Xeldrin 40 mg (Capsule (Enteric Coated))
Unit Price: ৳ 9.00 (5 x 8: ৳ 360.00)
Strip Price: ৳ 72.00
Medicine Details
Category | Details |
---|---|
Generic | Omeprazole |
Company | Aci limited |
Also available as |
Indications
- Gastric and duodenal ulcer
- NSAID-associated duodenal and gastric ulcer
- Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
- Gastro-esophageal reflux disease
- Long-term management of acid reflux disease
- Acid-related dyspepsia
- Severe ulcerating reflux esophagitis
- Prophylaxis of acid aspiration during general anesthesia
- Zollinger-Ellison syndrome
- Helicobacter pylori-induced peptic ulcer
Pharmacology
- Inhibitor of gastric acid secretion
- Blocks hydrogen-potassium-adenosine triphosphatase (H⁺/K⁺ ATPase) enzyme system
- Onset of the antisecretory effect within one hour
- Maximum effect occurring within two hours
- Inhibition of secretion lasts up to 72 hours
- Gradual return of secretory activity over 3 to 5 days after discontinuation
Dosage
- 20 mg once daily for benign gastric and duodenal ulcer
- 40 mg daily in severe or recurrent cases of gastric ulcer
- 10-20 mg daily for prevention of relapse in duodenal ulcer
- 10-20 mg once daily for acid-related dyspepsia
- 40 mg on the preceding evening, then 40 mg 2-6 hours before surgery for prophylaxis of acid aspiration
- 20-120 mg daily for Zollinger-Ellison syndrome
Administration
- Direction for use of IV Injection
- Direction for use of IV Infusion
- Intravenous administration only
- Reconstitution and slow injection guidelines
Interaction
- Decreased intragastric acidity affecting ketoconazole absorption
- Metabolism through cytochrome P450 affecting diazepam, phenytoin, and warfarin elimination
- Plasma concentrations affected during concomitant administration with clarithromycin
- Increase in bioavailability of digoxin during simultaneous treatment
Contraindications
- Known hypersensitivity to Omeprazole
- Suspected gastric ulcer with possibility of malignancy
Side Effects
- Skin rash, urticaria, and pruritus
- Photosensitivity, bullous eruption, and erythema multiforme
- Diarrhoea, headache, constipation, and nausea/vomiting
- Dry mouth, stomatitis, and candidiasis
- Paraesthesia, dizziness, and feeling faint
- Reports of reversible mental confusion, agitation, depression, and hallucinations
- Arthritic and myalgic symptoms
- Increases in liver enzymes
Pregnancy & Lactation
- No adverse effects on pregnancy or fetus/newborn child
- No information available on passage into breast milk
- Discontinuation of breastfeeding if essential use is considered
Precautions & Warnings
- Avoid concomitant use with clopidogrel
- Increased risk for osteoporosis-related fractures with proton pump inhibitor (PPI) therapy
- Atrophic gastritis noted occasionally with long-term use
- Methotrexate toxicities with concomitant use of PPIs
Therapeutic Class
- Proton Pump Inhibitor
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children
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