Xelopes 20 mg (Capsule (Enteric Coated))
Unit Price: ৳ 5.02 (12 x 10: ৳ 602.40)
Strip Price: ৳ 50.20
Medicine Details
Category | Details |
---|---|
Generic | Omeprazole |
Company | Beacon pharmaceuticals plc |
Also available as |
Indications
- Treatment of gastric and duodenal ulcer
- Treatment of NSAID-associated duodenal and gastric ulcer
- Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
- Treatment of gastro-esophageal reflux disease
- Long-term management of acid reflux disease
- Treatment of acid-related dyspepsia
- Treatment of severe ulcerating reflux esophagitis
- Prophylaxis of acid aspiration during general anesthesia
- Treatment of Zollinger-Ellison syndrome
- Treatment of Helicobacter pylori-induced peptic ulcer
Pharmacology
- Inhibitor of gastric acid secretion
- Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
- Onset of antisecretory effect occurs within one hour
- Maximum effect occurs within two hours
- Inhibition of secretion lasts up to 72 hours
Dosage
- Dosage for benign gastric and duodenal ulcer
- Dosage for NSAID-associated duodenal or gastric ulcer
- Dosage for gastro-esophageal reflux disease
- Dosage for long-term management of acid reflux disease
- Dosage for acid-related dyspepsia
- Dosage for prophylaxis of acid aspiration
- Dosage for Zollinger-Ellison syndrome
- Dosage for Helicobacter pylori eradication regimen
- Pediatric use in severe ulcerating reflux esophagitis
Administration
- Use of IV Injection
- Use of IV Infusion
- Reconstitution of IV injection
- IV infusion over a period of 20-30 minutes
- IV infusion over a period of 20-30 minutes or more
- IV infusion over a period of at least 2 to 5 minutes
Interaction
- Absorption of ketoconazole may be reduced during treatment
- Metabolized in the liver through cytochrome P450
- Can delay the elimination of diazepam, phenytoin and warfarin
- Monitoring of patients receiving warfarin or pheytoin
- Plasma concentrations of Xelopes and clarithromycin are increased
- No evidence of interaction with phenacetin, theophylline, caffeine, propranolol, metoprolol, cyclosporin, lidocaine, quinidine, estradiol, amoxycillin or antacids
- Increased bioavailability of digoxin
Contraindications
- Known hypersensitivity to Omeprazole
- Gastric ulcer suspected of malignancy
Side Effects
- Skin rash, urticaria and pruritus
- Photosensitivity, bullous eruption, erythema multiforme, angioedema and alopecia
- Diarrhoea and headache
- Constipation, nausea/vomiting, flatulence and abdominal pain
- Dry mouth, stomatitis and candidiasis
- Paraesthesia, dizziness, light headedness and feeling faint
- Somnolence, insomnia and vertigo
- Mental confusion, agitation, depression and hallucinations
- Arthritic and myalgic symptoms
- Blurred vision, taste disturbance, peripheral oedema
- Increased sweating, gynaecomastia, leucopenia, thrombocytopenia, agranulocytosis, pancytopenia, anaphylactic shock, malaise, fever, bronchospasm, encephalopathy
- Increases in liver enzymes
Pregnancy & Lactation
- No adverse effects of Omeprazole on pregnancy or fetus
- Use during pregnancy
- No information available on passage into breast milk or effects on the neonate
- Discontinuation of breastfeeding if essential
Precautions & Warnings
- Avoid concomitant use of clopidogrel
- Increased risk for osteoporosis-related fractures
- Atrophic gastritis noted occasionally
- Concomitant use with methotrexate may lead to toxicities
Therapeutic Class
- Proton Pump Inhibitor
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children
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