Glophen D 0.1%+0.5% (Ophthalmic Solution)

5 ml drop: ৳ 70.00

Medicine Details

Category Details
Generic Dexamethasone chloramphenicol
Company Globe pharmaceuticals ltd

Title

  • Glophen D Ophthalmic Solution

Categories

  • Medicine
  • Ophthalmic Solution

Description

  • Glophen D is an ophthalmic solution indicated for various eye conditions such as acute purulent conjunctivitis, corneal ulcers, keratitis, otitis externa, and otitis media. It contains Dexamethasone, a glucocorticoid with anti-inflammatory and anti-allergic properties, as well as Chloramphenicol, a broad spectrum bacteriostatic antibiotic.

Dimensions

  • 10ml bottle

Color Options

  • Clear solution

Functions

  • Treatment of acute purulent conjunctivitis
  • Treatment of corneal ulcers
  • Treatment of otitis externa and otitis media
  • Anti-inflammatory action on the anterior segment of the eye
  • Bacteriostatic and antibiotic effect on gram-negative and gram-positive organisms

Materials

  • Contains Dexamethasone, Chloramphenicol, and other inactive ingredients

Technical Specifications

  • Rapid absorption after oral administration with a half-life of about 190 minutes
  • Topical application for systemic effects
  • Broad-spectrum bacteriostatic activity
  • Inhibits bacterial protein synthesis at an early stage

Design Elements

  • Clear bottle packaging
  • Distinct labeling
  • Easy-to-use dropper

Usability Features

  • Applicator for dropping into the eye
  • Clear dosage instructions
  • Long shelf life before and after opening (30 days)

Indications

  • Acute purulent conjunctivitis
  • Corneal ulcers
  • Keratitis disciformis
  • Post-herpetic keratitis
  • Allergic conjunctivitis
  • Otitis externa
  • Otitis media

Pharmacology

  • Dexamethasone has anti-inflammatory and anti-allergic action on the anterior segment of the eye
  • Chloramphenicol is absorbed rapidly after administration and exerts its antibacterial effect by inhibiting bacterial protein synthesis

Dosage & Administration

  • For bacterial conjunctivitis: 1-2 drops every 2 hours for 2 days then 1-2 drops every 4 hours for the next 5 days
  • For corneal ulcers: 2 drops every 15 minutes for 6 hours, then 2 drops every 30 minutes for the rest of the first day, followed by hourly instillation on the second day, and subsequent 4-hour intervals for 3-14 days
  • For otitis externa and otitis media: 2-3 drops every 2-3 hours initially, with decreased frequency as clinical signs improve

Interaction

  • Increase in anticoagulant effect when absorbed with warfarin
  • Inhibition of Chloramphenicol's action when given with Phenobarbital
  • Reduced efficacy of Dexamethasone with phenytoin, phenobarbitone, ephedrine, and rifampicin

Contraindications

  • Epithelial herpes simplex cornealis
  • Fungal, viral, or tuberculous infections of the eye
  • Glaucoma
  • Myelosuppression during previous Chloramphenicol exposure
  • Hypersensitivity to Chloramphenicol or Dexamethasone Phosphate

Side Effects

  • Transient ocular burning or discomfort
  • Stinging, redness, itching, conjunctivitis
  • Foreign body sensation, photophobia, blurred vision
  • Dryness and eye pain
  • Elevation of intraocular pressure with possible glaucoma

Pregnancy & Lactation

  • Caution in pregnancy and nursing mothers, with use only if potential benefit justifies potential risk

Precautions & Warnings

  • Consideration of persistent fungal infections with prolonged corticosteroid dosing
  • Potential for posterior subcapsular cataract formation and glaucoma with prolonged steroid use
  • Monitoring of intraocular pressure is needed
  • Possible overgrowth of non-susceptible organisms with prolonged antibiotic use
  • Discontinue if new infections appear and institute alternative therapy

Therapeutic Class

  • Ophthalmic steroid-antibiotic combined preparations

Storage Conditions

  • Keep in a cool, dry place away from light
  • Keep out of the reach of children
  • Do not use after 30 days of first opening

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