Glophen D 0.1%+0.5% (Ophthalmic Solution)
5 ml drop: ৳ 70.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Dexamethasone chloramphenicol |
| Company | Globe pharmaceuticals ltd |
Title
- Glophen D Ophthalmic Solution
Categories
- Medicine
- Ophthalmic Solution
Description
- Glophen D is an ophthalmic solution indicated for various eye conditions such as acute purulent conjunctivitis, corneal ulcers, keratitis, otitis externa, and otitis media. It contains Dexamethasone, a glucocorticoid with anti-inflammatory and anti-allergic properties, as well as Chloramphenicol, a broad spectrum bacteriostatic antibiotic.
Dimensions
- 10ml bottle
Color Options
- Clear solution
Functions
- Treatment of acute purulent conjunctivitis
- Treatment of corneal ulcers
- Treatment of otitis externa and otitis media
- Anti-inflammatory action on the anterior segment of the eye
- Bacteriostatic and antibiotic effect on gram-negative and gram-positive organisms
Materials
- Contains Dexamethasone, Chloramphenicol, and other inactive ingredients
Technical Specifications
- Rapid absorption after oral administration with a half-life of about 190 minutes
- Topical application for systemic effects
- Broad-spectrum bacteriostatic activity
- Inhibits bacterial protein synthesis at an early stage
Design Elements
- Clear bottle packaging
- Distinct labeling
- Easy-to-use dropper
Usability Features
- Applicator for dropping into the eye
- Clear dosage instructions
- Long shelf life before and after opening (30 days)
Indications
- Acute purulent conjunctivitis
- Corneal ulcers
- Keratitis disciformis
- Post-herpetic keratitis
- Allergic conjunctivitis
- Otitis externa
- Otitis media
Pharmacology
- Dexamethasone has anti-inflammatory and anti-allergic action on the anterior segment of the eye
- Chloramphenicol is absorbed rapidly after administration and exerts its antibacterial effect by inhibiting bacterial protein synthesis
Dosage & Administration
- For bacterial conjunctivitis: 1-2 drops every 2 hours for 2 days then 1-2 drops every 4 hours for the next 5 days
- For corneal ulcers: 2 drops every 15 minutes for 6 hours, then 2 drops every 30 minutes for the rest of the first day, followed by hourly instillation on the second day, and subsequent 4-hour intervals for 3-14 days
- For otitis externa and otitis media: 2-3 drops every 2-3 hours initially, with decreased frequency as clinical signs improve
Interaction
- Increase in anticoagulant effect when absorbed with warfarin
- Inhibition of Chloramphenicol's action when given with Phenobarbital
- Reduced efficacy of Dexamethasone with phenytoin, phenobarbitone, ephedrine, and rifampicin
Contraindications
- Epithelial herpes simplex cornealis
- Fungal, viral, or tuberculous infections of the eye
- Glaucoma
- Myelosuppression during previous Chloramphenicol exposure
- Hypersensitivity to Chloramphenicol or Dexamethasone Phosphate
Side Effects
- Transient ocular burning or discomfort
- Stinging, redness, itching, conjunctivitis
- Foreign body sensation, photophobia, blurred vision
- Dryness and eye pain
- Elevation of intraocular pressure with possible glaucoma
Pregnancy & Lactation
- Caution in pregnancy and nursing mothers, with use only if potential benefit justifies potential risk
Precautions & Warnings
- Consideration of persistent fungal infections with prolonged corticosteroid dosing
- Potential for posterior subcapsular cataract formation and glaucoma with prolonged steroid use
- Monitoring of intraocular pressure is needed
- Possible overgrowth of non-susceptible organisms with prolonged antibiotic use
- Discontinue if new infections appear and institute alternative therapy
Therapeutic Class
- Ophthalmic steroid-antibiotic combined preparations
Storage Conditions
- Keep in a cool, dry place away from light
- Keep out of the reach of children
- Do not use after 30 days of first opening