Dextor-T 0.1%+0.3% (Ophthalmic Solution)

Indications

• Steroid responsive inflammatory ocular conditions
• Chronic anterior uveitis
• Corneal injury from chemical radiation or thermal burns
• Penetration of foreign bodies
• Combination with an anti-infective component

Pharmacology

• Bactericidal activity of Tobramycin
• Inhibition of normal protein synthesis in susceptible bacteria
• Inhibition of protein synthesis due to action on ribosome
• Inhibition of phospholipase A2 by Dexamethasone
• Inhibition of chemo-tactic infiltration of neutrophils by Dexamethasone

Dosage & Administration

• Eye Drops: 1 drop into the conjunctival sac 3-5 times per day
• Eye Drops: Increased dosage to 1 drop every 2 hours for initial 24 to 48 hours
• Eye Ointment: Apply a small amount into the conjunctival sac 3-4 times per day
• Pediatric Use: Safety and effectiveness not established below 2 years

Interaction

• No specific interaction studies performed with Dextor-T eye drops
• Interval of 10 minutes between successive applications with other topical ophthalmic medicines

Contraindications

• Epithelial herpes simplex keratitis (dendritic keratitis)
• Vaccinia and varicella
• Mycobacterial infection of the eye
• Hypersensitivity to any component of the medication

Side Effects

• Hypersensitivity and localized ocular toxicity with Tobramycin
• Lid itching, swelling, and conjunctival erythema
• Elevation of intraocular pressure, possible glaucoma
• Optic nerve damage, posterior subcapsular cataract formation, delayed wound healing with steroid component

Pregnancy & Lactation

• Use during pregnancy if potential benefit justifies potential risk to fetus
• Caution during nursing as systemic absorption to produce detectable quantities in human milk

Precautions & Warnings

• Consider possibility of fungal infections after long-term steroid dosing
• Prolonged use may result in overgrowth of non-susceptible organisms, including fungi
• Cross-sensitivity to other aminoglycoside antibiotics
• Discontinue use and institute appropriate therapy if hypersensitivity develops

Overdose Effects

• Overdose through local administration not known
• Specific measures to reduce resorption in case of accidental oral intake

Therapeutic Class

• Ophthalmic steroid - antibiotic combined preparations

Storage Conditions

• Store at room temperature
• Close the bottle immediately after use
• Do not use for longer than one month after opening

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