Xerosec 20 mg (Capsule (Enteric Coated))
Unit Price: ৳ 5.02 (10 x 10: ৳ 502.00)
Strip Price: ৳ 50.20
Medicine Details
Category | Details |
---|---|
Generic | Omeprazole |
Company | Synovia pharma plc |
Also available as |
Indications
- Gastric and duodenal ulcer
- NSAID-associated duodenal and gastric ulcer
- Gastro-esophageal reflux disease
- Long-term management of acid reflux disease
- Acid-related dyspepsia
- Severe ulcerating reflux esophagitis
- Prophylaxis of acid aspiration during general anesthesia
- Zollinger-Ellison syndrome
- Helicobacter pylori-induced peptic ulcer
Pharmacology
- Inhibitor of gastric acid secretion
- Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
- Onset of antisecretory effect within one hour
- Maximum effect occurring within two hours
- Inhibition of secretion lasts up to 72 hours
- Return of secretory activity within 3 to 5 days after discontinuation
Dosage
- 20 mg once daily for benign gastric and duodenal ulcer
- 40 mg once daily for severe or recurrent cases of ulcer
- 20 mg once daily for 4 weeks in NSAID-associated duodenal or gastric ulcer
- 10-20 mg once daily for acid-related dyspepsia
- 40 mg dose for prophylaxis of acid aspiration during general anesthesia
- 60 mg once daily for Zollinger-Ellison syndrome
- 20 mg twice daily for Helicobacter pylori eradication regimen
Administration
- IV Injection given slowly over a period of 5 minutes
- IV Infusion given over a period of 20-30 minutes or more
- Reconstituted solution should be used within 4 hours
- Reconstituted solution should not be mixed with other drugs in the same infusion set
Interaction
- Decreased absorption of ketoconazole during Xerosec treatment
- Delayed elimination of diazepam, phenytoin, and warfarin
- Increased plasma concentrations of Xerosec and clarithromycin
- No interaction with phenacetin, theophylline, caffeine, propranolol, etc
Contraindications
- Known hypersensitivity to omeprazole
- Suspected gastric ulcer without exclusion of malignancy
Side Effects
- Skin rash, urticaria, pruritus
- Photosensitivity, bullous eruption, erythema multiforme
- Diarrhea, headache, constipation, nausea/vomiting
- Dry mouth, stomatitis, candidiasis
- Dizziness, somnolence, insomnia, vertigo
- Mental confusion, agitation, depression, hallucinations
- Arthritic and myalgic symptoms
- Blurred vision, taste disturbance, peripheral edema
- Increases in liver enzymes
Pregnancy & Lactation
- No adverse effects on pregnancy or fetus/newborn child
- Use during pregnancy deemed safe
- Discontinue breastfeeding if essential to use omeprazole
Precautions & Warnings
- Avoid concomitant use with clopidogrel
- Possible association with increased risk for osteoporosis-related fractures
- Atrophic gastritis observed in long-term treatment
- Potential for methotrexate toxicities with concomitant use
Therapeutic Class
- Proton Pump Inhibitor
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children
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