Xerosec 40 mg (Capsule (Enteric Coated))
Unit Price: ৳ 8.02 (3 x 10: ৳ 240.60)
Strip Price: ৳ 80.20
Medicine Details
Category | Details |
---|---|
Generic | Omeprazole |
Company | Synovia pharma plc |
Also available as |
Indications
- Gastric and duodenal ulcer
- NSAID-associated duodenal and gastric ulcer
- Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
- Gastro-esophageal reflux disease
- Long-term management of acid reflux disease
- Acid-related dyspepsia
- Severe ulcerating reflux esophagitis
- Prophylaxis of acid aspiration during general anesthesia
- Zollinger-Ellison syndrome
- Helicobacter pylori-induced peptic ulcer
Pharmacology
- Inhibitor of gastric acid secretion
- Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
- Onset of the antisecretory effect occurs within one hour
- Maximum effect occurs within two hours
- Inhibition of secretion lasts up to 72 hours
- Secretory activity returns gradually over 3 to 5 days after discontinuation
Dosage
- 20 mg once daily for benign gastric and duodenal ulcer
- 40 mg daily for severe or recurrent cases of gastric ulcer
- Maintenance dose of 20 mg once daily for recurrent duodenal ulcer
- 10-20 mg daily for prevention of relapse in duodenal ulcer
- 20 mg once daily for NSAID-associated duodenal or gastric ulcer
- 20 mg once daily for gastro-esophageal reflux disease
- 40 mg once daily for refractory gastro-esophageal reflux disease
- 10-20 mg daily for long-term management of acid reflux disease
- 10-20 mg once daily for acid-related dyspepsia
- 40 mg for prophylaxis of acid aspiration before surgery
- Initial 60 mg once daily for Zollinger-Ellison syndrome
- Recommended dose of 20 mg twice daily for H. pylori eradication regimen
Administration
- Omeprazole IV injection is for intravenous administration only
- IV injection should be given slowly over a period of 5 minutes
- IV infusion should be given over a period of 20-30 minutes or more
- Reconstituted solution should be used within 4 hours
- IV infusion solution should be used within 12 hours when dissolved in saline
- IV infusion solution should be used within 6 hours when dissolved in 5% Dextrose
Interaction
- Decreased intragastric acidity may reduce absorption of ketoconazole
- Metabolised in the liver through cytochrome P450, can delay the elimination of diazepam, phenytoin, and warfarin
- Concomitant treatment with Xerosec can affect plasma concentrations of other drugs
- No evidence of interaction with phenacetin, theophylline, caffeine, propranolol, and more
Contraindications
- Known hypersensitivity to omeprazole
- Exclusion of malignancy before treatment if gastric ulcer is suspected
Side Effects
- Adverse reactions have generally been mild and reversible
- Skin rash, urticaria and pruritus have been reported
- Diarrhoea and headache reported in some cases
- Other gastrointestinal reactions include constipation, nausea/vomiting, flatulence, and abdominal pain
- Dizziness, light headedness, and feeling faint associated with treatment
- Reversible mental confusion, agitation, depression, and hallucinations in severely ill patients
Pregnancy & Lactation
- Results from prospective epidemiological studies indicate no adverse effects on pregnancy
- No information available on the passage of omeprazole into breast milk or its effects on the neonate
- Safety and effectiveness not established in pediatric patients less than 18 years of age
Precautions & Warnings
- Avoid concomitant use of clopidogrel and Xerosec
- PPI therapy may be associated with an increased risk for osteoporosis-related fractures
- Atrophic gastritis noted occasionally in patients treated long-term with Xerosec
- Concomitant use of PPIs with methotrexate may lead to methotrexate toxicities
Therapeutic Class
- Proton Pump Inhibitor
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children
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