Orinil 5 mg (Tablet)
Unit Price: ৳ 0.21 (100's pack: ৳ 21.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Diazepam |
| Company | Doctors chemical works ltd |
Indications
- Short-term treatment of anxiety
- Treatment of excitation and agitation
- Management of fear and aggressiveness
- Anxiety reactions caused by stressed conditions
- Anxiety states with somatic expression
- Premedication for surgical procedures
- Insomnia of hospitalized patients
- Acute alcohol withdrawal
- Status epilepticus
- Febrile convulsions
Description
- Benzodiazepine derivative
- Safe tranquillizer
- Anxiolytic
- Anticonvulsant
- Central muscle relaxant
- Widely used in obstetrics
- Control of status epilepticus
Pharmacology
- Binds to GABA receptor
- Potentiates effect of GABA
- Opens chloride ion channels into cells
- Rapid and complete absorption after oral administration
- Peak plasma concentration within 15-90 minutes
- Mean plasma half-life of 30 hours
- Metabolized in the liver
- Only traces of unchanged drug excreted in urine
- Eliminated with the feces
- Rectal administration is significantly absorbed
Dosage & Administration
- Oral dosage for anxiety and insomnia
- IM/slow IV injection for severe acute anxiety and febrile convulsion in children
- Rectal administration for children
- Dosage adjustment for elderly or debilitated patients
Interaction
- Contraindicated with alcohol
- Potential for increased sedation with neuroleptics, hypnotics, sedative antihistamines, and CNS depressants
- Drug clearance affected by concomitant administration of phenobarbitone and cimetidine
- Inhibition of metabolism by omeprazole and isoniazide
Contraindications
- Myasthenia gravis
- Pulmonary insufficiency
- Respiratory depression
- Hypersensitivity to benzodiazepine
Side Effects
- Somnolence
- Dizziness
- Light headedness
- Confusion
- Ataxia
Pregnancy & Lactation
- Crosses placental barrier
- Passes into breast milk
- Avoided if possible during pregnancy and lactation
Precautions & Warnings
- Prolonged use and abrupt withdrawal to be avoided
- Caution in respiratory disease, muscle weakness, history of drug or alcohol abuse, and hepatic or renal impairment
Overdose Effects
- Sedation
- Muscle weakness
- Profound sleep or paradoxical excitation
- Ataxia
- Hypotonia
- Hypotension
- Respiratory depression
- Coma and death in severe cases
Therapeutic Class
- Benzodiazepine sedatives
- Centrally acting Skeletal Muscle Relaxants
- Primary anti-epileptic drugs
Storage Conditions
- Store in a cool and dry place
- Protected from light