Tensareal 5 mg (Tablet)
Unit Price: ৳ 0.25 (100's pack: ৳ 25.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Diazepam |
| Company | Indo bangla pharmaceutical |
Indications
- Short-term treatment of mild to moderate anxiety
- Treatment of excitation and agitation
- Management of fear and aggressiveness
- Management of anxiety reactions caused by stressed conditions
- Management of anxiety states with somatic expression
- Management of acute alcohol withdrawal
- Control of status epilepticus
- Premedication for surgical procedures
- Management of febrile convulsions
- Treatment of insomnia in hospitalized patients
Description
- Benzodiazepine derivative
- Safe tranquillizer
- Anxiolytic
- Anticonvulsant
- Central muscle relaxant
- Widely used in obstetrics
- Available in intravenous form
Pharmacology
- Attaches to specific site on the GABA receptor
- Potentiates the effect of GABA
- Opens chloride ion channels into cells
- Rapid absorption after oral administration
- Peak plasma concentration reached within 15-90 minutes
- Mean plasma half-life of 30 hours
- 98-99% plasma protein binding
- Metabolized in the liver
- Traces of unchanged drug excreted in urine
- Metabolites excreted through bile into the intestine
- Eliminated with the feces
- Significant absorption after rectal administration
Dosage & Administration
- Oral administration for anxiety and insomnia
- IM/slow IV injection for severe acute anxiety and febrile convulsion
- Rectal administration for children
- Different doses for adults and children
- Increased dosage if necessary
Interaction
- Not recommended with alcohol
- Increased sedation with concomitant use of neuroleptics, hypnotics, sedative antihistamines and CNS depressants
- Enhanced clearance with phonobarbitone
- Decreased clearance with cimetidine
- Inhibition of metabolism by omeprazole and isoniazide
Contraindications
- Myasthenia gravis
- Pulmonary insufficiency
- Respiratory depression
- Hypersensitivity to benzodiazepine
Side Effects
- Somnolence
- Dizziness
- Light headedness
- Confusion
- Ataxia
- Well tolerated at lower doses
Pregnancy & Lactation
- Crosses placental barrier
- Passes into breast milk
- Avoided if possible during pregnancy and lactation
- US FDA pregnancy category D
Precautions & Warnings
- Avoid prolonged use and abrupt withdrawal
- Caution in respiratory disease and muscle weakness
- Use with caution in history of drug or alcohol abuse
- Use with caution in cases of hepatic or renal impairment
Overdose Effects
- Sedation
- Muscle weakness
- Profound sleep or paradoxical excitation
- More severe effects may include ataxia, hypotonia, hypotension, and respiratory depression
- Rarely coma and death
Therapeutic Class
- Benzodiazepine sedatives
- Centrally acting skeletal muscle relaxants
- Primary anti-epileptic drugs
Storage Conditions
- Store in a cool and dry place
- Temperature below 25˚C
- Protected from light