Asector 40 mg (Capsule (Enteric Coated))

Unit Price: ৳ 9.03 (7 x 4: ৳ 252.87)
Strip Price: ৳ 36.12

Medicine Details

Category Details
Generic Esomeprazole
Company Novo healthcare and pharma ltd
Also available as
Asector 20 mg capsule Asector 40 mg injection

Title and Categories

  • Asector 40 mg Capsule
  • Proton Pump Inhibitor
  • Lifestyle Medicine
  • Digestive Health
  • Gastrointestinal Relief

Indications

  • Relief from chronic heartburn symptoms
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection
  • Treatment for Zollinger-Ellison Syndrome
  • Management of Acid-related Dyspepsia
  • Healing of Duodenal & Gastric Ulcers

Dosage Forms

  • Oral tablet
  • Oral capsule
  • Oral suspension
  • IV injection
  • IV infusion

Dosage Instructions

  • 20 mg or 40 mg Once Daily for 4-8 Weeks (Erosive Esophagitis)
  • 20 mg Once Daily (Maintenance of Healing of Erosive Esophagitis)
  • 20 mg Once Daily for 4 Weeks (Symptomatic GERD)
  • Triple Therapy for Helicobacter Pylori eradication
  • 20-80 mg once daily (Zollinger-Ellison Syndrome)
  • 20-40 mg once daily for 2-4 weeks (Acid-related Dyspepsia)
  • 20 mg once daily for 2-4 weeks (Duodenal Ulcer)
  • 20-40 mg once daily for 4-8 weeks (Gastric Ulcer)

Administration Instructions

  • Swallow tablet or capsule whole, one hour before a meal
  • Prepare oral suspension by mixing with water
  • Administer IV injection or infusion as per specified duration

Pharmacology

  • Mechanism of Action: Inhibition of H+/K+-ATPase
  • Absorption: Peak plasma levels at approximately 1.5 hours
  • Distribution: 97% bound to plasma proteins
  • Metabolism: Extensively metabolized by CYP enzymes
  • Excretion: Plasma elimination half-life of approximately 1–1.5 hours

Interactions

  • CYP Metabolism:
    • Metabolized by CYP2C19 and CYP3A4
    • No clinically relevant interactions with specific CYP enzymes
  • Potential Interference:
    • Interference with absorption of drugs affected by gastric pH
  • Specific Drug Interactions:
    • Potential interaction with diazepam, ketoconazole, iron salts, and digoxin

Contraindications

  • Known hypersensitivity to any of the formulation

Side Effects

  • Headache
  • Diarrhoea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth

Use in Special Populations

  • Paediatric Use: Safety and effectiveness not established
  • Geriatric Use: No overall differences in safety and efficacy observed
  • Hepatic Insufficiency: No dosage adjustment recommended for mild to moderate insufficiency
  • Renal Insufficiency: Pharmacokinetics not expected to be altered

Overdose Effects

  • Acute toxicity signs: reduced motor activity, changes in respiratory frequency, tremor, convulsions
  • No specific antidote known
  • Symptomatic and supportive treatment recommended

Storage Conditions

Store at temperature not exceeding 30°C, protect from light and moisture

Chemical Structure

  • Molecular Formula: C17H19N3O3S
  • Chemical Structure Image: https://medex.com.bd/storage/res/g-res-433-esomeprazole-chemical-structure-Tj2Jfp1VmPkRjNXznKqC.svg

Commonly Asked Questions

  • Uses:
    • Treats gastroesophageal reflux disease (GERD), ulcers, and other conditions involving excess stomach acid
  • Side Effects: Includes headaches, diarrhea, nausea, and other common symptoms
  • Pregnancy & Breastfeeding: No specific side effects reported, discuss with doctor if essential

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