Curacid 40 mg (Capsule (Enteric Coated))

Unit Price: ৳ 9.50 (5 x 4: ৳ 190.00)
Strip Price: ৳ 38.00

Medicine Details

Category Details
Generic Esomeprazole
Company Rangs pharmaceuticals ltd
Also available as
Curacid 20 mg capsule

Indications

  • Relief from chronic heartburn symptoms
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection in patients with duodenal ulcer disease
  • Treatment of Zollinger-Ellison Syndrome
  • Management of Acid related Dyspepsia
  • Treatment of Duodenal & Gastric ulcer

Pharmacology

  • Proton pump inhibitor
  • Suppresses gastric acid secretion
  • Specific inhibition of the H+/K+-ATPase
  • Better acid control than racemic proton pump inhibitors
  • Peak plasma levels occur at approximately 1.5 hours
  • 97% bound to plasma proteins
  • Extensively metabolized in the liver by CYP enzymes
  • Plasma elimination half-life of approximately 1-1.5 hours

Dosage

  • 20 mg or 40 mg Once Daily for healing of erosive esophagitis
  • 20 mg Once Daily for maintenance of healing of erosive esophagitis
  • 20 mg Once Daily for symptomatic GERD
  • Triple Therapy: Esomeprazole 40 mg Once Daily, Amoxicillin 1000 mg Twice Daily, Clarithromycin 500 mg Twice Daily for Helicobacter pylori eradication
  • Dose for Zollinger-Ellison Syndrome: 20-80 mg once daily
  • 20-40 mg once daily for acid-related Dyspepsia
  • 20 mg once daily for Duodenal ulcer, 20-40 mg once daily for Gastric ulcer
  • IV Injection/Infusion dosage for various conditions

Administration

  • Tablet or capsule should be swallowed whole and taken one hour before a meal
  • Oral Suspension should be taken as per specific instructions
  • IV Injection for specific conditions

Interaction

  • Metabolized in the liver by CYP2C19 and CYP3A4
  • Unlikely to inhibit CYPs 1A2, 2A6, 2C9, 2D6, 2E1, and 3A4
  • No clinically significant interactions with specific drugs
  • Potential interference with CYP2C19
  • Increased plasma levels observed with certain drug co-administrations

Contraindications

  • Hypersensitivity to any of the formulation

Side Effects

  • Headache
  • Diarrhoea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • Animal studies indicate no teratogenic effects
  • Excretion in milk not studied
  • Breast-feeding should be discontinued if esomeprazole is essential

Precautions & Warnings

  • Symptomatic response does not preclude the presence of gastric malignancy
  • Specific instructions for patients with difficulty swallowing capsules
  • Use of antacids while taking esomeprazole

Use in Special Populations

  • Safety and effectiveness not established in paediatric patients
  • No overall differences in safety and efficacy observed between the elderly and younger individuals
  • No dosage adjustment recommended for patients with mild to moderate hepatic insufficiency
  • No alteration in pharmacokinetics expected in patients with renal impairment

Overdose Effects

  • Lethal dose observed in rats
  • Signs of acute toxicity include reduced motor activity, respiratory changes, tremor, and convulsions
  • No specific antidote
  • Supportive and symptomatic treatment recommended

Storage Conditions

  • Store at a temperature not exceeding 30°C
  • Protect from light and moisture
  • Keep out of reach of children

Chemical Structure

  • Molecular Formula: C17H19N3O3S
  • Chemical Structure: Image available

Common Questions about Curacid 40 mg Capsule

  • Proton pump inhibitor used to treat various conditions
  • Multiple uses including relief from heartburn, healing of erosive esophagitis, and prevention of recurrence
  • Common side effects include headaches, diarrhea, nausea, and others
  • Consultation required for pregnant or breastfeeding individuals
  • Quick tips for ensuring effectiveness and managing side effects

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