Emep 40 mg/vial (IV Injection)

40 mg vial: ৳ 90.00

Medicine Details

Category Details
Generic Esomeprazole
Company Aristopharma ltd
Also available as
Emep 20 mg tablet Emep 20 mg capsule Emep 40 mg capsule

Indications

  • Relief from chronic heartburn symptoms
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection
  • Zollinger-Ellison Syndrome
  • Acid related Dyspepsia
  • Duodenal & Gastric ulcer

Pharmacology

  • Proton pump inhibitor
  • Suppression of gastric acid secretion
  • Absorption peak at approximately 1.5 hours
  • Distribution: 97% bound to plasma proteins
  • Metabolized in the liver by the cytochrome P450 (CYP) enzyme system
  • Plasma elimination half-life of approximately 1–1.5 hours

Dosage

  • 20 mg or 40 mg once daily for healing of erosive esophagitis for 4-8 weeks
  • 20 mg once daily for maintenance of healing of erosive esophagitis
  • 20 mg once daily for symptomatic GERD for 4 weeks
  • Triple therapy for Helicobacter pylori eradication
  • 20-80 mg once daily for Zollinger-Ellison Syndrome
  • 20-40 mg once daily for Acid-related Dyspepsia
  • 20 mg once daily for Duodenal ulcer for 2-4 weeks
  • 20-40 mg once daily for Gastric ulcer for 4-8 weeks

Administration

  • Tablet or capsule should be swallowed whole and taken one hour before a meal
  • Oral Suspension: Should be stirred well and consumed within 30 minutes. If administered through a tube, use an appropriately sized syringe
  • IV Injection: Administered intravenously over a period of at least 3 minutes

Interaction

  • Extensively metabolized in the liver by CYP2C19 and CYP3A4
  • Potentially interferes with the absorption of drugs where gastric pH is an important determinant of bioavailability
  • No clinically significant interactions with certain drugs

Contraindications

  • Contraindicated in patients with known hypersensitivity to any of the formulation

Side Effects

  • Headache
  • Diarrhoea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • Excretion in milk not studied
  • Breast-feeding should be discontinued if essential

Precautions & Warnings

  • Symptomatic response does not preclude the presence of gastric malignancy
  • Tablet should be taken at least one hour before meals
  • Antacids may be used while taking the medicine

Use in Special Populations

  • Safety and effectiveness in paediatric patients not established
  • No overall differences in safety and efficacy observed between the elderly and younger individuals
  • No dosage adjustment recommended for patients with mild to moderate hepatic insufficiency
  • Pharmacokinetics not expected to be altered in renal impairment

Overdose Effects

  • A single oral dose at 510 mg/kg has been lethal to rats
  • No specific antidote known
  • Treatment should be symptomatic and supportive

Storage Conditions

  • Store at a temperature not exceeding 30°C in a dry place
  • Protect from light and moisture
  • Keep out of reach of children

Chemical Structure

  • Molecular Formula: C17H19N3O3S

Common Questions about Emep 40 mg/vial Injection

  • PPI for treating GERD, ulcers, and conditions involving too much stomach acid
  • Eases heartburn and relieves GERD symptoms
  • May cause common side effects like headaches, diarrhea, nausea, etc.
  • Consideration needed if pregnant or breastfeeding
  • Usually starts to work within a few hours of taking

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