Epleron 50 mg (Tablet)

Indications

• Congestive heart failure after an acute myocardial infarction
• Hypertension

Pharmacology

• Selective binding to mineralocorticoid receptor
• Blocks binding of aldosterone
• Regulation of blood pressure and CV disease pathophysiology
• Effects on epithelial and nonepithelial tissues

Dosage & Administration

• Recommended starting dose of 50mg once daily
• Titration to target dose of 50mg once daily
• Administration with or without food
• Use alone or in combination with other antihypertensive agents
• Dosage increase in inadequate blood pressure response

Interaction

• May increase risk of hyperkalaemia with ACE inhibitors and/or angiotension receptor blocker
• May reduce antihypertensive effect with NSAIDs, glucocorticoids, tetracosactide
• Enhance hypotensive effect of alpha-1 blockers, TCAs, amifostine, baclofen, neuroleptics
• May increase plasma level with mild to moderate CYP3A4 inhibitors

Contraindications

• Hyperkalaemia
• Severe renal impairment
• Severe hepatic impairment
• Concomitant use with potent CYP3A4 inhibitors
• Potassium-sparing diuretics

Side Effects

• Headache
• Dizziness
• Diarrhea
• Stomach pain
• Nausea
• Cough
• Flu-like symptoms
• Symptoms of serious allergic reactions like rash, itching, swelling, severe dizziness, trouble breathing

Pregnancy & Lactation

• No adequate and well-controlled studies in pregnant women
• Eplerenone should be used during pregnancy only if potential benefit justifies potential risk to the fetus
• Concentration in human breast milk after oral administration is unknown
• Decision should be made whether to discontinue nursing or discontinue the drug

Precautions & Warnings

• Use with caution in hyperkalemia
• Severe kidney disease
• Diabetic patients with congestive heart failure after an acute myocardial infarction including those with proteinuria

Use in Special Populations

• Pediatric use: safety and effectiveness not established
• Geriatric use: no differences in overall incidence of effectivity or safety observed in elderly patients

Overdose Effects

• Symptoms: Hyperkalaemia, hypotension
• Management: Symptomatic and supportive treatment
• Admin activated charcoal
• Initiate standard therapy for hyperkalaemia

Therapeutic Class

• Potassium-sparing diuretics
• Aldosterone antagonists

Storage Conditions

• Store below 30°C in a cool and dry place
• Protected from light and moisture
• Keep out of children’s reach

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