Recogen 2000 IU (IV/SC Injection)

2000 IU pre-filled syringe: ৳ 1,000.00

Medicine Details

Category	Details
Generic	Erythropoietin alfa
Company	Aci limited
Also available as	Recogen 3000 iu injection Recogen 5000 iu injection Recogen 10000 iu injection

Indications

Treatment of anemia in Chronic Kidney Disease (CKD) patients on dialysis and not on dialysis
Treatment of anemia in Zidovudine-treated HIV-infected patients
Treatment of anemia in patients undergoing myelosuppressive chemotherapy
Reduction of allogeneic RBC transfusions in noncardiac, nonvascular surgery patients
Prevention of anemia of prematurity in infants with low birth weight and premature gestational age

Description

Recombinant human erythropoietin (EPO) indicated for anemia treatment, expressed in Chinese hamster ovary cells, with a molecular weight of 30,400 daltons and identical to human urinary EPO

Dosage

Evaluation of Iron Stores and Nutritional Factors before treatment
Regular monitoring of hemoglobin levels for CKD patients
Dosing adjustments based on hemoglobin rate of rise, decline, and ESA responsiveness
Different starting doses for CKD patients on dialysis and not on dialysis, and Zidovudine-treated HIV-infected patients
Specific dosing regimen for cancer chemotherapy patients and prevention of anemia of prematurity in infants

Administration

Preparation and administration precautions such as not shaking the product, protecting syringe from light, and visual inspection for particulate matter and discoloration
Discard unused portions of Erythropoietin alfa

Interaction

Potential potentiation with the therapeutic administration of a haematinic agent such as ferrous sulphate in cases of deficiency

Contraindications

Uncontrolled hypertension
Serious allergic reactions to Erythropoietin alfa
Pure Red Cell Aplasia (PRCA) following treatment with any erythropoietin

Side Effects

Adverse reactions include hypertension, arthralgia, muscle spasm, pyrexia, dizziness, medical device malfunction, vascular occlusion, and upper respiratory tract infection in CKD patients
Adverse reactions in Zidovudine-treated HIV-infected Patients
Adverse reactions in Cancer Patients on Chemotherapy
Adverse reactions in Surgery Patients
Common fall in serum ferritin values in premature infants

Pregnancy & Lactation

No adequate and well-controlled studies in pregnant women
Reproduction toxicology in animal studies
Caution in nursing women, with consideration of the benefit of breast feeding to the child and the benefit of Erythropoietin alfa therapy to the woman

Overdose Effects

Wide therapeutic margin with potential for hemoglobin level elevation and severe hypertension

Therapeutic Class

Drugs for Haemolytic Hypoplastic & Renal Anemia

Storage Conditions

Store at 2ºC to 8ºC without freezing or shaking, maintaining temperature range until administration, and protecting from light