Recogen 10000 IU (IV/SC Injection)

10000 IU pre-filled syringe: ৳ 3,900.00

Medicine Details

Category	Details
Generic	Erythropoietin alfa
Company	Aci limited
Also available as	Recogen 2000 iu injection Recogen 3000 iu injection Recogen 5000 iu injection

Indications

Treatment of anemia due to Chronic Kidney Disease (CKD)
Treatment of anemia due to Zidovudine in HIV-infected patients
Reduction of allogeneic RBC transfusions in patients undergoing elective, noncardiac, nonvascular surgery
Prevention of anemia of prematurity in infants with a birth weight of 750 to 1500 gm and gestational age of less than 34 weeks

Description

Recombinant human erythropoietin (EPO) expressed in Chinese hamster ovary cells with a 165 amino acid sequence identical to human urinary EPO

Dosage

Monitor hemoglobin levels at least weekly until stable
Evaluate iron status in all patients before and during treatment
Adjust therapy based on hemoglobin rate of rise, rate of decline, and ESA responsiveness
Starting dose for adult patients with CKD on dialysis: 50 to 100 units/kg 3 times weekly intravenously or subcutaneously
Starting dose for Zidovudine-treated HIV-infected Patients: 100 units/kg as an intravenous or subcutaneous injection 3 times per week

Administration

Do not shake or freeze the Erythropoietin alfa
Protect syringe from light
Inspect visually for particulate matter and discoloration prior to administration
Discard unused portions of Erythropoietin alfa

Interaction

Effect may be potentiated by simultaneous therapeutic administration of a haematinic agent such as ferrous sulphate

Contraindications

Uncontrolled hypertension
Serious allergic reactions to Erythropoietin alfa
Patients who develop Pure Red Cell Aplasia (PRCA) following treatment with any erythropoietin

Side Effects

Hypertension, arthralgia, muscle spasm, pyrexia, dizziness, and upper respiratory tract infection in patients with CKD
Pyrexia, cough, rash, and injection site irritation in Zidovudine-treated HIV-infected Patients
Nausea, vomiting, myalgia, arthralgia, stomatitis, cough, weight decrease, leukopenia, bone pain, rash, hyperglycemia, headache, depression, dysphagia, hypokalemia, and thrombosis in cancer patients on chemotherapy
Nausea, vomiting, pruritus, headache, injection site pain, chills, and deep vein thrombosis in surgery patients
A fall in serum ferritin values in premature infants

Pregnancy & Lactation

Erythropoietin alfa should be used in pregnancy only if the potential benefit outweighs the potential risk to the foetus
Not recommended for pregnant or lactating surgical patients participating in an autologous blood predonation programme
Use with caution in nursing women, decision on whether to continue/discontinue therapy should consider the benefit of breast feeding to the child and the benefit of Erythropoietin alfa therapy to the woman

Overdose Effects

Recogen overdosage can cause hemoglobin levels above the desired level, managed with discontinuation or reduction of Recogen dosage and/or with phlebotomy, as clinically indicated. Severe hypertension has been observed following overdose with ESAs

Therapeutic Class

Drugs for Haemolytic Hypoplastic & Renal Anemia

Storage Conditions

Store at 2°C to 8°C, do not freeze or shake, store in original package to protect from light