Nipotin 10000 IU (IV/SC Injection)

10000 IU pre-filled syringe: ৳ 4,200.00

Medicine Details

Category Details
Generic Erythropoietin alfa
Company Aristopharma ltd
Also available as
Nipotin 2000 iu injection Nipotin 3000 iu injection Nipotin 4000 iu injection Nipotin 5000 iu injection

Indications

  • Treatment of anemia in Chronic Kidney Disease (CKD) patients on dialysis
  • Treatment of anemia in Chronic Kidney Disease (CKD) patients not on dialysis
  • Treatment of anemia in Zidovudine-treated HIV-infected patients
  • Reduction of allogeneic RBC transfusions in patients undergoing elective noncardiac nonvascular surgery
  • Prevention of anemia of prematurity in infants with specific birth weight and gestational age

Description

  • Recombinant human erythropoietin (EPO) expressed in Chinese hamster ovary cells
  • Has a 165 amino acid sequence identical to human urinary EPO
  • Apparent molecular weight of erythropoietin is about 30,400 daltons

Dosage

  • Evaluate iron status in all patients before and during treatment
  • Maintain iron repletion
  • Monitor hemoglobin levels at least weekly when initiating or adjusting therapy
  • Consider hemoglobin rate of rise, rate of decline, and ESA responsiveness when adjusting therapy
  • Do not increase the dose more frequently than once every 4 weeks

Administration

  • Do not shake the product
  • Protect syringe from light
  • Inspect visually for particulate matter and discoloration prior to administration

Interaction

  • Nipotin's effect may be potentiated by simultaneous therapeutic administration of a haematinic agent such as ferrous sulphate

Contraindications

  • Uncontrolled hypertension
  • Serious allergic reactions to Erythropoietin alfa
  • Patients who develop Pure Red Cell Aplasia (PRCA) following treatment with any erythropoietin

Side Effects

  • Adverse reactions in CKD patients: hypertension, arthralgia, muscle spasm, pyrexia, dizziness, medical device malfunction, vascular occlusion, upper respiratory tract infection
  • Adverse reactions in Zidovudine-treated HIV-infected Patients: pyrexia, cough, rash, injection site irritation
  • Adverse reactions in cancer patients on chemotherapy: nausea, vomiting, myalgia, arthralgia, stomatitis, cough, weight decrease, leukopenia, bone pain
  • Adverse reactions in surgery patients: nausea, vomiting, pruritus, headache, injection site pain, chills, deep vein thrombosis, cough, hypertension
  • Adverse reactions in premature infants: fall in serum ferritin values

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • Use in pregnancy only if potential benefit outweighs potential risk to the fetus
  • Not recommended for pregnant or lactating surgical patients participating in autologous blood predonation program
  • Caution advised in nursing women

Overdose Effects

  • Nipotin overdosage can cause hemoglobin levels above the desired level
  • Manage with discontinuation or reduction of Nipotin dosage and/or with phlebotomy
  • Cases of severe hypertension observed following overdose

Therapeutic Class

  • Drugs for Haemolytic Hypoplastic & Renal Anemia

Storage Conditions

  • Store at 2°C to 8°C
  • Do not freeze or shake
  • Store in original package to protect from light

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