Eposis 4000 IU (IV/SC Injection)

4000 IU pre-filled syringe: ৳ 1,935.80

Medicine Details

Category Details
Generic Erythropoietin alfa
Company Beacon pharmaceuticals plc
Also available as
Eposis 2000 iu injection Eposis 3000 iu injection Eposis 5000 iu injection Eposis 10000 iu injection

Title

  • Eposis

Categories

  • Medicine
  • Health
  • Pharmaceuticals

Description

  • Recombinant human erythropoietin (EPO) with 165 amino acid sequence
  • Expressed in Chinese hamster ovary cells
  • Molecular weight approximately 30,400 daltons

Indications

  • Treatment of anemia in chronic kidney disease (CKD) patients on dialysis and not on dialysis
  • Treatment of anemia in Zidovudine-treated HIV-infected patients
  • Treatment of anemia in patients undergoing myelosuppressive chemotherapy
  • Reduction of allogeneic RBC transfusions in patients undergoing elective, noncardiac, nonvascular surgery
  • Prevention of anemia of prematurity in infants with low birth weight and gestational age

Dosage

  • Evaluate iron status before and during treatment
  • Monitor hemoglobin levels at least weekly until stable, then monthly
  • Consider hemoglobin rate of rise, rate of decline, and ESA responsiveness
  • Starting dose and dose adjustments for CKD patients on dialysis and not on dialysis
  • Starting dose and dose adjustments for Zidovudine-treated HIV-infected patients
  • Starting dose and dose adjustments for patients on cancer chemotherapy
  • Administration via intravenous or subcutaneous route

Administration

  • Do not shake or freeze the product
  • Protect the syringe from light
  • Inspect visually for particulate matter and discoloration
  • Discard unused portions

Interaction

  • Simultaneous therapeutic administration with a haematinic agent may potentiate the effect

Contraindications

  • Uncontrolled hypertension
  • Serious allergic reactions to Erythropoietin alfa
  • Patients who develop Pure Red Cell Aplasia (PRCA) following treatment with any erythropoietin

Side Effects

  • Adverse reactions in CKD patients
  • Adverse reactions in Zidovudine-treated HIV-infected patients
  • Adverse reactions in cancer patients on chemotherapy
  • Adverse reactions in surgery patients
  • Common adverse reaction in premature infants

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • Reproduction toxicology shown in animal studies
  • Use in pregnancy only if potential benefit outweighs potential risk to the foetus
  • Not recommended for pregnant or lactating surgical patients participating in autologous blood predonation

Overdose Effects

  • Wide therapeutic margin
  • Hemoglobin levels may rise above desired level
  • Manage with discontinuation or reduction of dosage, and/or with phlebotomy
  • Cases of severe hypertension observed following overdose with ESAs

Therapeutic Class

  • Drugs for Haemolytic Hypoplastic & Renal Anemia

Storage Conditions

  • Store at 2°C to 8°C
  • Do not freeze or shake
  • Store in original package to protect from light

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