Eporen 3000 IU (IV/SC Injection)

3000 IU pre-filled syringe: ৳ 1,454.37

Medicine Details

Category Details
Generic Erythropoietin alfa
Company Square pharmaceuticals plc
Also available as
Eporen 5000 iu injection

Indications

  • Treatment of anemia in Chronic Kidney Disease (CKD)
  • Treatment of anemia in HIV-infected patients on Zidovudine
  • Treatment of anemia caused by myelosuppressive chemotherapy
  • Reduction of allogeneic RBC transfusions in noncardiac, nonvascular surgery patients
  • Prevention of anemia in premature infants

Description

  • Recombinant human erythropoietin (EPO)
  • Expressed in Chinese hamster ovary cells
  • 165 amino acid sequence identical to human urinary EPO
  • Apparent molecular weight of about 30,400 daltons

Dosage

  • Evaluation of iron stores and nutritional factors
  • Monitoring hemoglobin levels during therapy
  • Dosing adjustments based on hemoglobin response
  • Different starting doses for CKD patients on dialysis and not on dialysis
  • Dose adjustment for Zidovudine-treated HIV-infected Patients
  • Initiation of Erythropoietin alfa in cancer patients based on hemoglobin level

Administration

  • Preparation and administration instructions
  • Avoid shaking Erythropoietin alfa
  • Visual inspection for particulate matter and discoloration
  • Protection from light
  • Discarding unused portions of Erythropoietin alfa

Interaction

  • Effect potentiation by simultaneous administration of haematinic agent like ferrous sulphate

Contraindications

  • Uncontrolled hypertension
  • Serious allergic reactions to Erythropoietin alfa
  • Patients who develop Pure Red Cell Aplasia (PRCA) following treatment with any erythropoietin

Side Effects

  • Adverse reactions in CKD patients, Zidovudine-treated HIV-infected Patients, Cancer Patients, Surgery Patients, and Premature infants

Pregnancy & Lactation

  • Use of Erythropoietin alfa in pregnancy in chronic renal failure patients
  • Use of Erythropoietin alfa in pregnant or lactating surgical patients participating in an autologous blood predonation programme
  • Excretion of Erythropoietin alfa in human milk and caution for nursing women

Overdose Effects

  • Wide therapeutic margin
  • Potential hemoglobin level increase
  • Management with discontinuation or reduction of dosage and/or phlebotomy
  • Cases of severe hypertension observed

Therapeutic Class

  • Drugs for Haemolytic Hypoplastic & Renal Anemia

Storage Conditions

  • Temperature storage range of 2°C to 8°C
  • Avoid freezing or shaking
  • Protection from light

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