AmiCoxib 120 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Etoricoxib |
| Company | Amico laboratories ltd |
| Also available as |
Title
AmiCoxib 120 mg Tablet
Categories
- Medicine
- NSAIDs
- Pain Relief
Description
AmiCoxib is indicated for the symptomatic relief of Osteoarthritis (OA), Rheumatoid arthritis (RA), Ankylosing spondylitis, and the pain and signs of inflammation associated with acute gouty arthritis. It is also used for the short-term treatment of moderate pain associated with dental surgery.
Dosage
- Osteoarthritis: 30 mg once daily, increased to 60 mg if insufficient relief
- Rheumatoid arthritis: 90 mg once daily
- Ankylosing spondylitis: 90 mg once daily
- Acute gouty arthritis: 120 mg once daily for 8 days
- Postoperative dental surgery pain: 90 mg once daily, up to 3 days
Ingredient
Etoricoxib, C18H15ClN2O2S
Therapeutic Class
Non-steroidal Anti-inflammatory Drugs (NSAIDs)
Pharmacology
Etoricoxib is a potent, orally active cyclooxygenase-2 (COX-2) specific inhibitor, decreasing clinical signs and symptoms with decreased potential for GI toxicity and effects on platelet aggregation.
Storage Conditions
Store below 30°C, protect from light & moisture, keep out of reach of children
Duration of Effect
20-24 hours
Onset of Action
Within 1-2 hours, faster if taken without food
Pregnancy & Lactation
Not recommended for women attempting to conceive or breastfeeding
Precautions & Warnings
- Caution with elderly, prior history of gastrointestinal disease
- Monitor renal function in high-risk patients
- Exercise caution in patients with cardiac failure or hypertension
Common Questions
- Duration of effect
- Onset of action
- Pregnancy warnings
- Habit forming
- Breastfeeding warnings
- Alcohol safety
- Driving safety
- Kidney function impact
- Liver function impact
- Quick Tips for usage
Interaction
- Medicine:
- Oral anticoagulants
- Diuretics, ACE inhibitors, Angiotensin II Antagonists
- Acetylsalicylic Acid
- Ciclosporin and tacrolimus
- Lithium
- Food & Others: Take without regard to meals
Side Effects
- Palpitation
- Fatigue
- Influenza-like symptoms
- Dry Mouth
- Taste disturbance
- Atrial fibrillation
- Myalgia
- Arthralgia
- Confusion
- Hallucinations
Contraindications
- Hypersensitivity to active substance or excipients
- Active peptic ulceration or GI bleeding
- Pregnancy, lactation
- Severe hepatic dysfunction
- Estimated renal creatinine clearance <30 ml/min
- Inflammatory bowel disease
- Congestive heart failure
Overdose Effects
No significant toxicity observed up to 500 mg single dose or 150 mg/day for 21 days
Chemical Structure
C18H15ClN2O2S
Drug Interactions
- Oral anticoagulants
- Diuretics, ACE inhibitors, Angiotensin II Antagonists
- Acetylsalicylic Acid
- Ciclosporin and tacrolimus
- Lithium
Precautions & Monitoring
- Gastrointestinal complication risk
- Risk factors for cardiovascular events
- Renal function monitoring
- Patients with cardiac failure or hypertension
- Liver function test monitoring
Storage
Below 30°C, protect from light & moisture
Compound Summary
Molecular Formula: C18H15ClN2O2S, Chemical Structure provided
Caution for Elderly
Exercise caution with elderly patients, prior history of gastrointestinal disease
Caution for High-Risk Patients
Monitor renal function in high-risk patients
Safety for Patients with Cardiovascular Risk Factors
Consider treatment only after careful consideration
Safety for Patients with Renal Complications
Monitoring of renal function should be considered
Safety for Patients with Cardiac Conditions
Exercise caution in patients with history of cardiac failure, left ventricular dysfunction, or hypertension
Recommendations for Liver Function Tests
Regular monitoring of liver function tests during long-term treatment
Safety Concerns for Skin Reactions
Discontinue at the first appearance of skin rash, mucosal lesions, or any other sign of hypersensitivity