Esolok 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 7.00 (10 x 10: ৳ 700.00)
Strip Price: ৳ 70.00

Medicine Details

Category Details
Generic Esomeprazole
Company Ibn sina pharmaceuticals ltd
Also available as
Esolok 40 mg capsule Esolok 20 mg tablet Esolok 40 mg tablet Esolok 40 mg injection

Indications

  • Relief from chronic heartburn symptoms and other symptoms associated with GERD
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection in patients with duodenal ulcer disease
  • Zollinger-Ellison Syndrome
  • Acid-related Dyspepsia
  • Duodenal & Gastric ulcer

Pharmacology

  • Proton pump inhibitor
  • Suppression of gastric acid secretion
  • Specific inhibition of the H+/K+-ATPase
  • Better acid control than racemic proton pump inhibitors
  • Enteric-coated pellet formulation
  • Peak plasma levels occur at approximately 1.5 hours
  • Metabolized in the liver by the cytochrome P450 enzyme system
  • 97% bound to plasma proteins
  • Systemic bioavailability is approximately 90%
  • Plasma elimination half-life is approximately 1-1.5 hours
  • Triple combination therapy with clarithromycin and amoxicillin

Dosage

  • Oral dosage form for healing of erosive esophagitis, symptomatic GERD, Helicobacter pylori eradication, Zollinger-Ellison Syndrome, acid-related dyspepsia, duodenal & gastric ulcer
  • IV Injection or IV infusion for GERD with erosive esophagitis and risk reduction of rebleeding of gastric or duodenal ulcers
  • Different dosages for adult and pediatric patients
  • Dosage adjustments for patients with hepatic insufficiency

Administration

  • Tablet or capsule should be swallowed whole and taken one hour before a meal
  • Oral suspension administration instructions
  • IV injection preparation and administration
  • Specific instructions for administration through a nasogastric or gastric tube

Interaction

  • Extensively metabolized in the liver by CYP2C19 and CYP3A4
  • Not likely to inhibit certain CYPs
  • Potential interference with CYP2C19
  • Inhibition of gastric acid secretion
  • Drug interactions with phenytoin, warfarin, quinidine, clarithromycin or amoxicillin
  • Potential interference with the absorption of certain drugs

Contraindications

  • Known hypersensitivity to any of the formulation

Side Effects

  • Headache
  • Diarrhea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • Animal studies revealed no teratogenic effects
  • Excretion of esomeprazole in milk not studied
  • Breastfeeding should be discontinued if esomeprazole use is considered essential

Precautions & Warnings

  • Symptomatic response to therapy does not preclude the presence of gastric malignancy
  • Specific instructions for patients taking esomeprazole capsules
  • Use of antacids
  • No established safety and effectiveness in pediatric patients
  • No overall differences in safety and efficacy observed between the elderly and younger individuals

Use in Special Populations

  • No established safety and effectiveness in pediatric patients
  • No overall differences in safety and efficacy observed between the elderly and younger individuals
  • No dosage adjustment recommended for patients with mild to moderate hepatic insufficiency
  • Pharmacokinetics not expected to be altered in patients with renal impairment

Overdose Effects

  • Lethal dose in rats
  • Signs of acute toxicity in rats
  • No specific antidote for esomeprazole
  • Expected protein binding and dialysis ineffectiveness
  • Symptomatic and supportive treatment recommended

Storage Conditions

  • Temperature not exceeding 30°C
  • Dry place
  • Protection from light and moisture
  • Keep out of reach of children

Chemical Structure

  • Molecular Formula: C17H19N3O3S
  • Chemical Structure image

Common Questions

  • Definition of Esolok 20 mg Capsule
  • Uses of Esolok 20 mg Capsule
  • Adverse effects of Esolok 20 mg Capsule
  • Safety of Esolok 20 mg Capsule for pregnant or breastfeeding individuals
  • Onset of action of Esolok 20 mg Capsule
  • Quick Tips

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