Esolok 20 mg (Capsule (Enteric Coated))
Unit Price: ৳ 7.00 (10 x 10: ৳ 700.00)
Strip Price: ৳ 70.00
Medicine Details
Category | Details |
---|---|
Generic | Esomeprazole |
Company | Ibn sina pharmaceuticals ltd |
Also available as |
Indications
- Relief from chronic heartburn symptoms and other symptoms associated with GERD
- Healing of erosive esophagitis
- Maintenance of healing of erosive esophagitis
- Eradication of Helicobacter pylori infection in patients with duodenal ulcer disease
- Zollinger-Ellison Syndrome
- Acid-related Dyspepsia
- Duodenal & Gastric ulcer
Pharmacology
- Proton pump inhibitor
- Suppression of gastric acid secretion
- Specific inhibition of the H+/K+-ATPase
- Better acid control than racemic proton pump inhibitors
- Enteric-coated pellet formulation
- Peak plasma levels occur at approximately 1.5 hours
- Metabolized in the liver by the cytochrome P450 enzyme system
- 97% bound to plasma proteins
- Systemic bioavailability is approximately 90%
- Plasma elimination half-life is approximately 1-1.5 hours
- Triple combination therapy with clarithromycin and amoxicillin
Dosage
- Oral dosage form for healing of erosive esophagitis, symptomatic GERD, Helicobacter pylori eradication, Zollinger-Ellison Syndrome, acid-related dyspepsia, duodenal & gastric ulcer
- IV Injection or IV infusion for GERD with erosive esophagitis and risk reduction of rebleeding of gastric or duodenal ulcers
- Different dosages for adult and pediatric patients
- Dosage adjustments for patients with hepatic insufficiency
Administration
- Tablet or capsule should be swallowed whole and taken one hour before a meal
- Oral suspension administration instructions
- IV injection preparation and administration
- Specific instructions for administration through a nasogastric or gastric tube
Interaction
- Extensively metabolized in the liver by CYP2C19 and CYP3A4
- Not likely to inhibit certain CYPs
- Potential interference with CYP2C19
- Inhibition of gastric acid secretion
- Drug interactions with phenytoin, warfarin, quinidine, clarithromycin or amoxicillin
- Potential interference with the absorption of certain drugs
Contraindications
- Known hypersensitivity to any of the formulation
Side Effects
- Headache
- Diarrhea
- Nausea
- Flatulence
- Abdominal pain
- Constipation
- Dry mouth
Pregnancy & Lactation
- No adequate and well-controlled studies in pregnant women
- Animal studies revealed no teratogenic effects
- Excretion of esomeprazole in milk not studied
- Breastfeeding should be discontinued if esomeprazole use is considered essential
Precautions & Warnings
- Symptomatic response to therapy does not preclude the presence of gastric malignancy
- Specific instructions for patients taking esomeprazole capsules
- Use of antacids
- No established safety and effectiveness in pediatric patients
- No overall differences in safety and efficacy observed between the elderly and younger individuals
Use in Special Populations
- No established safety and effectiveness in pediatric patients
- No overall differences in safety and efficacy observed between the elderly and younger individuals
- No dosage adjustment recommended for patients with mild to moderate hepatic insufficiency
- Pharmacokinetics not expected to be altered in patients with renal impairment
Overdose Effects
- Lethal dose in rats
- Signs of acute toxicity in rats
- No specific antidote for esomeprazole
- Expected protein binding and dialysis ineffectiveness
- Symptomatic and supportive treatment recommended
Storage Conditions
- Temperature not exceeding 30°C
- Dry place
- Protection from light and moisture
- Keep out of reach of children
Chemical Structure
- Molecular Formula: C17H19N3O3S
- Chemical Structure image
Common Questions
- Definition of Esolok 20 mg Capsule
- Uses of Esolok 20 mg Capsule
- Adverse effects of Esolok 20 mg Capsule
- Safety of Esolok 20 mg Capsule for pregnant or breastfeeding individuals
- Onset of action of Esolok 20 mg Capsule
- Quick Tips
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