Epizol 40 mg (Capsule (Enteric Coated))

Unit Price: ৳ 9.00 (3 x 10: ৳ 270.00)
Strip Price: ৳ 90.00

Medicine Details

Category Details
Generic Esomeprazole
Company Nipa pharmaceuticals ltd
Also available as
Epizol 20 mg capsule

Title

  • Epizol 40 mg Capsule

Categories

  • Medicine
  • Pharmaceuticals

Description

  • A proton pump inhibitor used to relieve chronic heartburn symptoms and other symptoms associated with GERD, for the healing of erosive esophagitis, for maintenance of healing of erosive esophagitis, in combination with amoxicillin and clarithromycin for eradication of Helicobacter pylori infection, for Zollinger-Ellison Syndrome, acid-related Dyspepsia, duodenal and gastric ulcer

Indications

  • Relieves chronic heartburn symptoms
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection
  • Treatment of Zollinger-Ellison Syndrome
  • Treatment of acid-related Dyspepsia
  • Treatment of duodenal and gastric ulcers

Pharmacology

  • Proton pump inhibitor that suppresses gastric acid secretion
  • Absorption: Peak plasma levels occur at approximately 1.5 hours after oral administration
  • Distribution: 97% bound to plasma proteins
  • Metabolism: Extensively metabolized in the liver by the cytochrome P450 (CYP) enzyme system
  • Excretion: Plasma elimination half-life is approximately 1-1.5 hours

Dosage

  • 20 mg or 40 mg oral dosage for healing of erosive esophagitis
  • 20 mg oral dosage for maintenance of healing of erosive esophagitis
  • 20 mg oral dosage for symptomatic GERD
  • 40 mg oral dosage for eradication of Helicobacter pylori infection
  • 20-80 mg oral dosage for Zollinger-Ellison Syndrome
  • 20-40 mg oral dosage for acid-related Dyspepsia
  • 20 mg oral dosage for duodenal ulcer
  • Intravenous dosage for various conditions based on patient age and weight

Administration

  • Tablet or capsule should be swallowed whole and taken one hour before a meal
  • Oral Suspension: Contents mixed with water and consumed immediately
  • IV Injection: Administered intravenously over a period of at least 3 minutes

Interaction

  • Metabolized in the liver by CYP2C19 and CYP3A4
  • No clinically relevant interactions with drugs metabolized by CYPs 1A2, 2A6, 2C9, 2D6, 2E1, and 3A4 expected
  • Potential interference with CYP2C19, leading to changes in clearance of certain drugs
  • Co-administration with clarithromycin has resulted in increases in plasma levels of Epizol and 14-hydroxyclarithromycin

Contraindications

  • Contraindicated in patients with known hypersensitivity to any of the formulation

Side effects

  • Most frequently occurring adverse events include headache, diarrhea, nausea, flatulence, abdominal pain, constipation, and dry mouth

Pregnancy lactation

  • No adequate and well-controlled studies in pregnant women
  • No teratogenic effects observed in animal studies
  • Excretion in milk not studied
  • Breastfeeding should be discontinued if essential

Precautions warnings

  • Symptomatic response to therapy does not preclude the presence of gastric malignancy
  • Administration at least one hour before meals
  • Use of antacids while taking Epizol
  • Instructions for patients who have difficulty swallowing capsules

Special populations

  • No established safety and effectiveness in pediatric patients
  • No overall differences in safety and efficacy observed between the elderly and younger individuals
  • No dosage adjustment recommended for mild to moderate hepatic insufficiency
  • No alterations expected in patients with renal impairment

Overdose effects

  • Toxicity reported in animal studies at high doses
  • Symptomatic and supportive treatment recommended in case of overdosage
  • No specific antidote known

Storage conditions

  • Store at a temperature not exceeding 30°C in a dry place
  • Protect from light and moisture
  • Keep out of reach of children

Chemical structure

  • Molecular Formula: C17H19N3O3S
  • Chemical Structure: Image of chemical structure provided

Common questions

  • What is Epizol 40 mg Capsule?
  • What is Epizol 40 mg Capsule used for?
  • What are the side effects of Epizol 40 mg Capsule?
  • Can I take Epizol 40 mg Capsule if I am pregnant or breastfeeding?
  • Quick Tips for using Epizol 40 mg Capsule

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