Esomo 20 mg (Capsule (Enteric Coated))
Unit Price: ৳ 6.02 (6 x 10: ৳ 361.20)
Strip Price: ৳ 60.20
Medicine Details
Category | Details |
---|---|
Generic | Esomeprazole |
Company | Amulet pharmaceuticals ltd |
Also available as |
Indications
- Relief from chronic heartburn symptoms and other symptoms associated with GERD
- Healing of erosive esophagitis
- Maintenance of healing of erosive esophagitis
- Eradication of Helicobacter pylori infection in patients with duodenal ulcer disease
- Zollinger-Ellison Syndrome
- Acid-related Dyspepsia
- Duodenal and Gastric ulcer
Pharmacology
- Proton pump inhibitor
- Specific inhibition of the H+/K+-ATPase in the gastric parietal cell
- First single optical isomer of proton pump inhibitor
- Enteric-coated pellet formulation of esomeprazole magnesium
- Gastric acid suppression
- Metabolized in the liver by cytochrome P450 (CYP) enzyme system
- Plasma elimination half-life of approximately 1-1.5 hours
- High plasma protein binding (97%)
- Extensive metabolism in the liver
- Minimal excretion in urine
Dosage
- Oral dosage form
- Healing of erosive esophagitis: 20mg or 40mg once daily for 4-8 weeks
- Symptomatic GERD: 20mg once daily for 4 weeks
- Helicobacter pylori eradication: Esomeprazole 40mg once daily for 10 days
- IV Injection: 20mg or 40mg once daily for adult patients
- Pediatric patients dosage based on body weight
- Dosage adjustment for risk reduction of rebleeding of gastric or duodenal ulcers
Administration
- Tablet or capsule should be swallowed whole and taken one hour before a meal
- Oral suspension should be taken with water and within a specific time frame
- IV Injection solution for injection preparation and administration instructions
Interaction
- Extensively metabolized in the liver by CYP2C19 and CYP3A4
- Potential interference with absorption of certain drugs
- No clinically significant interactions with specific drugs
- Inhibition of gastric acid secretion
Contraindications
- Known hypersensitivity to any of the formulation
Side Effects
- Headache
- Diarrhea
- Nausea
- Flatulence
- Abdominal pain
- Constipation
- Dry mouth
Pregnancy & Lactation
- No adequate and well-controlled studies in pregnant women
- Animal studies show no teratogenic effects
- Excretion of esomeprazole in milk not studied
- Breastfeeding discontinuation if essential use of esomeprazole
Precautions & Warnings
- Symptomatic response does not preclude the presence of gastric malignancy
- Instructions for patients with difficulty swallowing capsules
- Use of antacids while taking esomeprazole
Use in Special Populations
- Safety and effectiveness not established in pediatric patients
- No overall differences in safety and efficacy observed in the elderly
- No dosage adjustment recommended for patients with mild to moderate hepatic insufficiency
- Pharmacokinetics not expected to be altered in patients with renal impairment
Overdose Effects
- Lethal effects observed in animal studies at high doses
- Symptomatic and supportive treatment recommended in case of overdose
Storage Conditions
- Temperature not exceeding 30°C
- Dry place
- Protection from light and moisture
- Keep out of reach of children
Chemical Structure
- Molecular Formula: C17H19N3O3S
- Chemical Structure Image: URL to image of chemical structure
Common Questions about Esomo 20 mg Capsule
- Usage: Proton pump inhibitor for treating various conditions related to stomach acid
- Side Effects: Headache, diarrhea, nausea, flatulence, abdominal pain, constipation, dry mouth
- Pregnancy & Breastfeeding: Consult a doctor for risk assessment
- Onset of Action: Usually starts working within a few hours
Related Brands
- Esomo 40 mg (Capsule (Enteric Coated)) - amulet-pharmaceuticals-ltd
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