Esomo 40 mg (Capsule (Enteric Coated))
Unit Price: ৳ 8.03 (5 x 6: ৳ 240.90)
Strip Price: ৳ 48.18
Medicine Details
Category | Details |
---|---|
Generic | Esomeprazole |
Company | Amulet pharmaceuticals ltd |
Also available as |
Indications
- Relief from chronic heartburn symptoms and other symptoms associated with GERD
- Healing of erosive esophagitis
- Maintenance of healing of erosive esophagitis
- Eradication of Helicobacter pylori infection in patients with duodenal ulcer disease
- Zollinger-Ellison Syndrome
- Acid related Dyspepsia
- Treatment of duodenal and gastric ulcers
Pharmacology
- Mode of Action: Proton pump inhibitor that suppresses gastric acid secretion
- Absorption: Peak plasma levels occur at approximately 1.5 hours after oral administration
- Distribution: 97% bound to plasma proteins
- Metabolism: Extensively metabolized in the liver by the cytochrome P450 enzyme system
- Excretion: Plasma elimination half-life is approximately 1–1.5 hours
Dosage
- Oral Dosage Form:
- Healing of Erosive Esophagitis: 20 mg or 40 mg Once Daily for 4-8 Weeks
- Symptomatic GERD: 20 mg Once Daily for 4 Weeks
- Helicobacter Pylori Eradication: Triple Therapy with Esomeprazole 40 mg Once Daily for 10 days
- IV Injection or IV Infusion: Dosage varies for adult and pediatric patients
Administration
- Tablet or Capsule: Should be swallowed whole and taken one hour before a meal
- Oral Suspension: Should be taken with water and consumed within 30 minutes
- IV Injection: Must be administrated intravenously over a period of at least 3 minutes
Interaction
- Metabolism: Extensively metabolized in the liver by CYP2C19 and CYP3A4
- Inhibition: Potential interference with the absorption of drugs where gastric pH is essential for bioavailability
Contraindications
Contraindicated in patients with known hypersensitivity to any of the formulation
Side Effects
- Headache
- Diarrhea
- Nausea
- Flatulence
- Abdominal Pain
- Constipation
- Dry Mouth
Pregnancy & Lactation
No adequate and well-controlled studies in pregnant women, excretion in milk not studied
Precautions & Warnings
Symptomatic response to therapy does not preclude the presence of gastric malignancy
Use in Special Populations
- No established safety and effectiveness in pediatric patients
- No overall differences in safety and efficacy observed between the elderly and younger individuals
Overdose Effects
Lethal dose in rats, may cause reduced motor activity, respiratory changes, tremor, and convulsions
Storage Conditions
Store at a temperature not exceeding 30°C in a dry place, protect from light and moisture
Chemical Structure
Molecular Formula: C17H19N3O3S, Chemical Structure image available
Commonly Asked Questions
- Uses of Esomeprazole
- Side Effects
- Pregnancy & Breastfeeding
- Onset of Action
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